EXOSC2 and ADAMTS13

Data Source:
HPRD (in vitro)

		EXOSC2	ADAMTS13
Description		exosome component 2	ADAM metallopeptidase with thrombospondin type 1 motif 13
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Extracellular Space Endoplasmic Reticulum Lumen Cell Surface Extracellular Matrix
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding 7S RNA Binding	Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing	Proteolysis Cell-matrix Adhesion Integrin-mediated Signaling Pathway Glycoprotein Metabolic Process Response To Toxic Substance Response To Amine Protein Processing Platelet Activation Extracellular Matrix Organization Response To Potassium Ion Peptide Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases			Thrombotic thrombocytopenic purpura; Moschcowitz disease; Schulman-Upshaw syndrome
GWAS			Activated partial thromboplastin time ( 22703881) ADAMTS13 activity ( 25934476) ADAMTS13 levels ( 29296746) Blood protein levels ( 29875488 28240269) Circulating fibroblast growth factor 23 levels ( 30217807) Coagulation factor levels ( 23267103) Cobalt levels ( 26025379) Gut microbiota (functional units) ( 27694959) Liver enzyme levels ( 18940312) Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Pancreatic cancer ( 25086665) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Interacting Genes		18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408	1 interacting genes: VWF
Entrez ID		23404	11093
HPRD ID		03758	04994
Ensembl ID		ENSG00000130713	ENSG00000160323
Uniprot IDs		B3KQW2 Q13868	Q76LX8
PDB IDs		2NN6 6D6Q 6D6R 6H25	3GHM 3GHN 3VN4 6QIG
Enriched GO Terms of Interacting Partners?
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