FNBP4 and SYNJ1

Data Source:
HPRD (in vitro)

		FNBP4	SYNJ1
Description		formin binding protein 4	synaptojanin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Speck	Cytosol Microtubule Vesicle Membrane Membrane Coat Clathrin Coat Of Coated Pit Terminal Bouton Perinuclear Region Of Cytoplasm Synaptic Membrane Presynapse
	Molecular Function	Protein Binding	RNA Binding Phosphatidylinositol-3-phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity SH3 Domain Binding Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity
	Biological Process		Phosphatidylinositol Biosynthetic Process Neurotransmitter Transport Brain Development Learning Synaptic Vesicle Priming Synaptic Vesicle Uncoating Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Membrane Organization Positive Regulation Of Endosome Organization
Pathways			Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Alcohol use disorder (consumption score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Free thyroxine concentration ( 30367059) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Medication use (antiglaucoma preparations and miotics) ( 31015401) Neuroticism ( 29255261) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698)	Platelet reactivity in response to clopidogrel treatment ( 32472697)
Interacting Genes		10 interacting genes: CSNK2A1 FYN ITSN1 ITSN2 KHDRBS1 LBR PLXNA2 PRPF40A SNRPB SYNJ1	24 interacting genes: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 GRB2 ITSN1 LRRK2 PACSIN1 PACSIN2 PACSIN3 PPP3CA SH3BP1 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SORBS2
Entrez ID		23360	8867
HPRD ID		10996	09182
Ensembl ID		ENSG00000109920	ENSG00000159082
Uniprot IDs		Q8N3X1	A0A0D9SGJ6 B9EGN3 C9JFZ1 J3KQV8 O43426 Q05CZ1
PDB IDs			1W80 2DNR 2VJ0
Enriched GO Terms of Interacting Partners?
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