NEDD4L and BMPR1A

Data Source:
BioGRID (pull down)

		NEDD4L	BMPR1A
Description		NEDD4 like E3 ubiquitin protein ligase	bone morphogenetic protein receptor type 1A
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Multivesicular Body Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome	Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Ion Channel Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding BMP Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Regulation Of Membrane Depolarization Ubiquitin-dependent Protein Catabolic Process Sodium Ion Transport Cellular Sodium Ion Homeostasis Excretion Response To Metal Ion Protein Ubiquitination Viral Life Cycle Water Homeostasis Cell Differentiation Regulation Of Protein Stability Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Regulation Of Dendrite Morphogenesis Regulation Of Membrane Repolarization Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Dendrite Extension Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Caveolin-mediated Endocytosis	In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Negative Regulation Of Smooth Muscle Cell Migration Stem Cell Population Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Hindlimb Morphogenesis Dorsal Aorta Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Roof Of Mouth Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Heart Formation BMP Signaling Pathway Involved In Heart Development Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Fibrous Ring Of Heart Morphogenesis Regulation Of Neural Crest Cell Differentiation Regulation Of Cellular Senescence
Pathways		Budding and maturation of HIV virion Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Stimuli-sensing channels Antigen processing: Ubiquitination & Proteasome degradation	Signaling by BMP
Drugs			Dibotermin alfa
Diseases			Hereditary mixed polyposis syndrome Juvenile polyposis syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Childhood body mass index ( 33045005) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Gamma glutamyl transferase levels ( 29403010) Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Manganese levels ( 26025379) Response to amphetamines ( 22952603)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Refractive error ( 32231278) White blood cell count ( 32888494)
Interacting Genes		133 interacting genes: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT3 AMOT APEX2 ARHGDIA ARRDC3 AURKC BBX BMPR1A C7orf50 CACNB1 CAMK1D CDC34 CDK3 CDK5 CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 GORAB GRIA1 H1-0 HAX1 IFRD2 IKBKB KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP2 MAP3K2 MAP3K20 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NEAT1 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 PBX1 PIK3CA PIP4P2 PRKX PRR16 PRRG1 PSMD4 PYM1 RANBP10 RASL10B RASL11B RHOB RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SMAD2 SMAD3 SMAD7 SNCA SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2N ULK1 VDAC2 WBP2 WNK4 YWHAG YWHAZ YY1 ZADH2 ZC3HAV1L ZDHHC3	45 interacting genes: ACVR1 ALDOB AOPEP BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 CDK8 CTSV FANCC FBP1 FBP2 FKBP1A FKBP1B GALNT12 GDF5 GDF6 GDF9 HOXC8 HRAS IGFBP3 MAP2K1 MSANTD3 NEDD4 NEDD4L OTUB1 RASA1 SEC61B SF3B4 SFRP2 SFRP4 SMAD1 TAB1 TDGF1 TGFB1 TGFBRAP1 TRMO USP15 XPA ZMYND11 ZNF189
Entrez ID		23327	657
HPRD ID		05903	03192
Ensembl ID		ENSG00000049759	ENSG00000107779
Uniprot IDs		A0A024R281 A0A024R2A4 B7Z2P9 B7Z6K0 Q96PU5	P36894
PDB IDs		2LAJ 2LB2 2LTY 2MPT 2NSQ 2ONI 3JVZ 3JW0 5HPK	1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?