FBXW11 and ZNF281

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		FBXW11	ZNF281
Description		F-box and WD repeat domain containing 11	zinc finger protein 281
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Kinetochore Nucleus Nuclear Envelope Centrosome Cytosol Microtubule Associated Complex Cytoplasmic Microtubule SCF Ubiquitin Ligase Complex Neuron Projection Neuronal Cell Body Axon Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Dimerization Activity Microtubule Plus-end Binding Dynein Complex Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Protein Dephosphorylation Nuclear Migration Germ Cell Development Retrograde Axonal Transport Viral Process Wnt Signaling Pathway Protein Ubiquitination Microtubule Organizing Center Organization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Vesicle Transport Along Microtubule Rhythmic Process Brain Morphogenesis T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Regulation Of Microtubule Motor Activity	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Embryonic Body Morphogenesis Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Stem Cell Differentiation
Pathways		Activation of NF-kappaB in B cells Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Height ( 28552196 20881960 25282103 25429064 23563607 31562340) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Antisaccade task score ( 31596458) Myopia ( 27182965) Neurofibrillary tangles ( 31497858) Prepulse inhibition of the startle response ( 31596458) Refractive error ( 32231278)
Interacting Genes		25 interacting genes: AGTR1 BHLHE41 BTRC CDC25A CSNK1E CUL1 DAPK1 GLI2 GSK3B IFNAR1 KDR MCL1 NFKB1 NFKBIA PPP1CC PPP2R1B PPP2R5E PRKACA PRLR PTEN TBC1D4 TRIM21 UBE2D3 WEE1 ZNF281	7 interacting genes: CD247 EGLN1 FBXW11 MYC PIK3R3 STAT3 ZBTB16
Entrez ID		23291	23528
HPRD ID		07294	11702
Ensembl ID		ENSG00000072803	ENSG00000162702
Uniprot IDs		B4DH70 Q9UKB1	B3KMX4 Q9Y2X9
PDB IDs		6WNX
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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