ARC and SPTBN4

Data Source:
BioGRID (pull down)

		ARC	SPTBN4
Description		activity regulated cytoskeleton associated protein	spectrin beta, non-erythrocytic 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Plasma Membrane Cell Cortex Actin Cytoskeleton Early Endosome Membrane Neuronal Cell Body Dendritic Spine Membrane Raft Neuronal Ribonucleoprotein Granule Postsynaptic Density Membrane Postsynaptic Endosome Glutamatergic Synapse Extracellular Vesicle	Cytoplasm Cytosol Actin Filament Plasma Membrane Adherens Junction Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Node Of Ranvier Paranode Region Of Axon Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Exosome Cell Body Fiber
	Molecular Function	MRNA Binding Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Endocytosis Cytoskeleton Organization Endoderm Development Learning Long-term Memory Anterior/posterior Pattern Specification Cell Migration Regulation Of Cell Morphogenesis Regulation Of Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission MRNA Transport Protein Homooligomerization Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Regulation Of Dendritic Spine Morphogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Intercellular Transport Regulation Of Long-term Synaptic Potentiation Regulation Of Long-term Synaptic Depression Positive Regulation Of AMPA Receptor Activity	MAPK Cascade Regulation Of Sodium Ion Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axonogenesis Axon Guidance Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Protein Localization To Plasma Membrane
Pathways		NGF-stimulated transcription NGF-stimulated transcription	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Automobile speeding propensity ( 30643258)	Antibody level in response to infection ( 25758998) Carotid intima media thickness (mean) ( 31801372) Hemoglobin levels ( 32327693) Pulse pressure ( 30578418)
Interacting Genes		7 interacting genes: CSRP2 KRT15 S100P SH2D4A SPTBN4 TBX18 UBE3A	15 interacting genes: ANK3 ARC CDC37 CELSR3 CENPU CLK1 DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1
Entrez ID		23237	57731
HPRD ID		12469	09372
Ensembl ID		ENSG00000198576	ENSG00000160460
Uniprot IDs		Q7LC44	Q9H254
PDB IDs
Enriched GO Terms of Interacting Partners?
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