FLT3LG and FLT3

Data Source:
HPRD (in vivo)

		FLT3LG	FLT3
Description		fms related receptor tyrosine kinase 3 ligand	fms related receptor tyrosine kinase 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Integral Component Of Membrane	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Glucocorticoid Receptor Binding Protein Self-association Protein-containing Complex Binding
	Biological Process	MAPK Cascade Signal Transduction Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Proliferation Embryonic Hemopoiesis	MAPK Cascade Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Animal Organ Regeneration Positive Regulation Of Kinase Activity Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation
Pathways		PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants	PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation FLT3 mutants bind TKIs STAT5 activation downstream of FLT3 ITD mutants KW2449-resistant FLT3 mutants semaxanib-resistant FLT3 mutants crenolanib-resistant FLT3 mutants gilteritinib-resistant FLT3 mutants lestaurtinib-resistant FLT3 mutants midostaurin-resistant FLT3 mutants pexidartinib-resistant FLT3 mutants ponatinib-resistant FLT3 mutants quizartinib-resistant FLT3 mutants sorafenib-resistant FLT3 mutants sunitinib-resistant FLT3 mutants tandutinib-resistant FLT3 mutants linifanib-resistant FLT3 mutants tamatinib-resistant FLT3 mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs			Sorafenib Sunitinib XL999 Tandutinib ABT-869 Lestaurtinib Midostaurin Ponatinib Nintedanib Fostamatinib Gilteritinib Brigatinib Fedratinib Amuvatinib Quizartinib Pexidartinib Pralsetinib
Diseases			Acute myeloid leukemia (AML)
GWAS		Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)	Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494) Psoriasis ( 25854761) Rapid automised naming of digits ( 30741946) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Tourette syndrome ( 30818990) White blood cell count ( 32888494 27863252) White blood cell count (monocyte) ( 28158719)
Interacting Genes		4 interacting genes: FLT3 KITLG KRTAP5-9 PFN2	17 interacting genes: CBL CBLB ERBB2 FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN11 PTPN12 PTPN6 SH3BP2 SLA SOCS1 SRC UBE2L6
Entrez ID		2323	2322
HPRD ID		02477	00635
Ensembl ID		ENSG00000090554	ENSG00000122025
Uniprot IDs		B7ZLY4 M0QYM9 P49771	P36888
PDB IDs		1ETE 3QS7 3QS9	1RJB 3QS7 3QS9 4RT7 4XUF 5X02 6IL3 6JQR
Enriched GO Terms of Interacting Partners?
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