MESD and LY96

Data Source:
BioGRID (two hybrid)

		MESD	LY96
Description		mesoderm development LRP chaperone	lymphocyte antigen 96
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane	Extracellular Space Plasma Membrane Endosome Membrane Intrinsic Component Of Plasma Membrane Lipopolysaccharide Receptor Complex
	Molecular Function	Molecular_function Protein Binding Identical Protein Binding Low-density Lipoprotein Particle Receptor Binding	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity Protein Binding Coreceptor Activity Toll-like Receptor 4 Binding
	Biological Process	Ossification Protein Folding Phagocytosis Mesoderm Development Wnt Signaling Pathway Protein Localization To Cell Surface Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Cellular Defense Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Detection Of Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Necroptotic Process Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway
Pathways			ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs			Morphine (R)-3-hydroxytetradecanoic acid Lauric acid Myristic acid
Diseases
GWAS			Blood protein levels ( 29875488) Carotid plaque burden (smoking interaction) ( 24954085) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Postoperative atrial fibrillation in coronary artery bypass grafting surgery ( 26385043)
Interacting Genes		75 interacting genes: ABCG8 ABITRAM ACBD7 ADAL AKIRIN2 AKNAD1 AKT1 APP ASH2L ATP6V1E1 ATP6V1E2 BORCS8 BORCS8-MEF2B BRD4 C17orf75 CCDC105 CDR2L CENATAC CENPH CHCHD1 CLP1 CNOT9 COL10A1 COL1A2 COX14 COX5A CUTC CYP4F11 DDX6 ENKD1 FAM13C FAM172A FARS2 FCER1A GEM GOLGA7 GPKOW GTPBP3 H2AB2 H2AB3 HSBP1L1 IGF1 KPNB1 LCE1A LRP5 LY96 MAGEB4 MAP1LC3B MCM9 MELTF MKNK2 MRM1 MTNR1A NRDE2 PMF1 PSMA5 QARS1 RCOR3 RFC3 SIK1B SMARCB1 SNX5 SNX7 TEX12 TEX48 TPM2 TREX2 TRMT2A TTC21A TTC23 TYMP UBQLN1 ZNF493 ZNF827 ZNF844	8 interacting genes: CALM1 CDKN2C LCN2 MESD MLH1 SMARCB1 TLR2 TLR4
Entrez ID		23184	23643
HPRD ID		12129	05579
Ensembl ID		ENSG00000117899	ENSG00000154589
Uniprot IDs		Q14696	Q9Y6Y9
PDB IDs			1T2Z 2E56 2E59 2Z65 3FXI 3ULA 4G8A
Enriched GO Terms of Interacting Partners?
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