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TAB2 and KRT85
Data Source:
BioGRID
(two hybrid)
TAB2
KRT85
Description
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
keratin 85
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Extracellular Space
Cytosol
Keratin Filament
Molecular Function
Protein Binding
Ubiquitin Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Structural Molecule Activity
Protein Binding
Biological Process
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Heart Development
Negative Regulation Of Autophagy
Response To Lipopolysaccharide
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Protein Kinase Activity
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Epidermis Development
Keratinization
Cornification
Pathways
Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Keratinization
Formation of the cornified envelope
Drugs
Diseases
Ectodermal dysplasia, pure hair-nail type (HNED)
GWAS
Breast cancer (
22383897
29059683
)
Coronary artery disease (
33020668
)
Diverticulitis (
28585551
)
Dupuytren's disease (
28886342
21732829
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Body mass index (
28552196
)
Interacting Genes
43 interacting genes:
APP
CAMK2A
CST9L
EIF2AK2
EMILIN1
ERBB4
FN1
FOSL1
GTF2I
HDAC1
HDAC3
HDAC5
HSF2BP
IKBKB
IKBKG
IRAK1
KRT85
MAP3K7
NCOR1
NFKB1
NR2C2
NUMBL
PPIL3
PPP2CB
SLC19A3
TAB1
TBL1X
TGM2
TNFRSF11A
TPM3
TRAF2
TRAF3IP1
TRAF6
TTN
UBC
UBE2I
VIM
VPS52
XIAP
YWHAZ
ZBTB16
ZFP64
ZNF143
26 interacting genes:
ALOX12
CLIC3
CREB5
CYSRT1
GNE
HAPLN2
KLHL38
KRT15
KRT16
KRT19
KRT25
KRT26
KRT27
KRT31
KRT33B
KRT34
KRT35
KRT36
KRT37
KRT38
KRT39
KRT40
LHX8
OTX1
TAB2
ZNF655
Entrez ID
23118
3891
HPRD ID
05483
04139
Ensembl ID
ENSG00000055208
ENSG00000135443
Uniprot IDs
B4DIR9
Q9NYJ8
B7Z7N3
F5GYI5
P78386
PDB IDs
2DAE
2WWZ
2WX0
2WX1
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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