RIMS1 and RAB37

Data Source:
HPRD (in vitro)

		RIMS1	RAB37
Description		regulating synaptic membrane exocytosis 1	RAB37, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Presynaptic Membrane Cell Projection Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone	Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Azurophil Granule Membrane Specific Granule Membrane
	Molecular Function	RNA Binding Protein Binding GTPase Regulator Activity Small GTPase Binding Ion Channel Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Intracellular Protein Transport Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Cell Differentiation Regulation Of Membrane Potential Regulated Exocytosis Secretion Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Positive Regulation Of Synaptic Transmission Response To Stimulus Acrosomal Vesicle Exocytosis Membrane Fusion Protein-containing Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Protein Transport Neutrophil Degranulation
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation	Neutrophil degranulation RAB geranylgeranylation
Drugs
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Chronotype ( 30696823) Cognitive performance ( 20125193) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Response to mTOR inhibitor (rapamycin) ( 24009623) Rosacea symptom severity ( 29771307) Schizophrenia ( 25056061 29483656 30285260) Squamous cell lung carcinoma ( 28604730) Triglyceride levels ( 32203549)	C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neurological blood protein biomarker levels ( 31320639) Neutrophil count ( 27863252) Platelet count ( 32888494) Plateletcrit ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		15 interacting genes: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH	5 interacting genes: EWSR1 MAL2 RAB5A RABGGTB RIMS1
Entrez ID		22999	326624
HPRD ID		09435	06702
Ensembl ID		ENSG00000079841	ENSG00000172794
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	A0A024R8K6 B3KPZ5 B7Z3L0 Q96AX2
PDB IDs		2CSS
Enriched GO Terms of Interacting Partners?
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