SORCS3 and F8

Data Source:
BioGRID (affinity chromatography technology)

		SORCS3	F8
Description		sortilin related VPS10 domain containing receptor 3	coagulation factor VIII
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Neuropeptide Receptor Activity	Copper Ion Binding Protein Binding Oxidoreductase Activity
	Biological Process	Neuropeptide Signaling Pathway Learning Memory Regulation Of Long-term Synaptic Depression	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway COPII Vesicle Coating
Pathways			Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma carboxylation, hypusine formation and arylsulfatase activation COPII-mediated vesicle transport Cargo concentration in the ER Defective factor IX causes thrombophilia Defective F8 accelerates dissociation of the A2 domain Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor Defective F8 binding to the cell membrane Defective cofactor function of FVIIIa variant Defective F8 secretion Defective F9 variant does not activate FX Defective F8 sulfation at Y1699
Drugs			Drotrecogin alfa Coagulation Factor IX (Recombinant) TB-402 Thrombin Protein C Human thrombin Thrombin alfa Vonicog Alfa Von Willebrand Factor Human Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol Damoctocog alfa pegol
Diseases			Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 29700475) Diabetic kidney disease ( 26305897) Diastolic blood pressure ( 30224653) Feeling miserable ( 29500382) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Mood instability ( 31168069) Multisite chronic pain ( 31194737) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Rosacea symptom severity ( 29771307) Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan) ( 28521775) Systolic blood pressure ( 30578418)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Factor VIII levels ( 30586737) Red blood cell traits ( 23446634) Thrombosis ( 26908601) Venous thromboembolism ( 31420334)
Interacting Genes		2 interacting genes: ATXN1 NGF	17 interacting genes: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 TSC22D2 UBQLN1 VWF
Entrez ID		22986	2157
HPRD ID		12100	02384
Ensembl ID		ENSG00000156395	ENSG00000185010
Uniprot IDs		Q86XB2 Q9UPU3	P00451
PDB IDs			1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV 4KI5 4PT6 4XZU 5K8D 6MF2
Enriched GO Terms of Interacting Partners?
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