MAST1 and FBXW4

Data Source:
BioGRID (two hybrid)

		MAST1	FBXW4
Description		microtubule associated serine/threonine kinase 1	F-box and WD repeat domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Axon Dendrite Neuron Projection Neuronal Cell Body	Ubiquitin Ligase Complex Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Brain Development Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Embryonic Limb Morphogenesis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways			Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Red blood cell count ( 29403010) Reticulocyte fraction of red cells ( 32888494)	Heel bone mineral density ( 30598549)
Interacting Genes		40 interacting genes: A2M AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH HSP90AB1 IFIT3 IFIT5 LONP1 LOXL4 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 RPS6KA1 SNTA1 SNTB2 STAMBPL1 UBE2D3	6 interacting genes: A2M CDC37 CUL1 ECSIT MAST1 RNF32
Entrez ID		22983	6468
HPRD ID		17469	06994
Ensembl ID		ENSG00000105613	ENSG00000107829
Uniprot IDs		Q9Y2H9	A0A384P5X9 P57775
PDB IDs		2M9X 3PS4
Enriched GO Terms of Interacting Partners?
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