SHANK2 and ANO1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		SHANK2	ANO1
Description		SH3 and multiple ankyrin repeat domains 2	anoctamin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Chloride Channel Complex Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Signaling Receptor Binding Calcium Activated Cation Channel Activity Intracellular Calcium Activated Chloride Channel Activity Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Iodide Transmembrane Transporter Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Cation Transport Chloride Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Iodide Transport Ion Transmembrane Transport Cellular Response To Heat Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Transmembrane Transport Cation Transmembrane Transport Cellular Response To Peptide Chloride Transmembrane Transport
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Stimuli-sensing channels
Drugs			Crofelemer
Diseases
GWAS		Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Basophil count ( 32888494) Birth weight ( 31043758) Childhood ear infection ( 27182965 28928442) Diastolic blood pressure ( 30224653) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Monobrow ( 27182965) Survival in rectal cancer ( 25866641) Systolic blood pressure ( 30578418)
Interacting Genes		19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		22941	55107
HPRD ID		04479	18202
Ensembl ID		ENSG00000162105	ENSG00000131620
Uniprot IDs		A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8	Q5XXA6 Q9NW72
PDB IDs
Enriched GO Terms of Interacting Partners?
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