RAB18 and UCN

Data Source:
BioGRID (proximity labelling technology)

		RAB18	UCN
Description		RAB18, member RAS oncogene family	urocortin
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endomembrane System Apical Plasma Membrane Secretory Granule Membrane Endoplasmic Reticulum Tubular Network	Extracellular Region Dendrite Varicosity Perikaryon Axon Terminus
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Neuropeptide Hormone Activity Protein Binding Histone Deacetylase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Eye Development Intracellular Protein Transport Small GTPase Mediated Signal Transduction Brain Development Viral Process Lipid Droplet Organization Neutrophil Degranulation Endoplasmic Reticulum Tubular Network Organization	Startle Response Inflammatory Response Response To Oxidative Stress G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Sensory Perception Of Sound Associative Learning Aerobic Respiration Negative Regulation Of Gene Expression Response To Auditory Stimulus Pancreatic Juice Secretion Positive Regulation Of Cell Growth Negative Regulation Of Histone Deacetylation Neuron Projection Development Negative Regulation Of Appetite Response To Estradiol Positive Regulation Of Interleukin-6 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Activation Of Protein Kinase A Activity Social Behavior Gastric Emptying Drinking Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Translation Positive Regulation Of DNA Replication Negative Regulation Of Blood Pressure Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Response To Pain Response To Glucocorticoid Positive Regulation Of Corticotropin Secretion Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Necrotic Cell Death Positive Regulation Of Calcium Ion Import Negative Regulation Of Neuron Death Negative Regulation Of Feeding Behavior Positive Regulation Of Behavioral Fear Response
Pathways		Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Class B/2 (Secretin family receptors) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases		Warburg micro syndrome
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ear infection ( 27182965 28928442) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hip circumference adjusted for BMI ( 28552196) Refractive error ( 32231278)	Crohn's disease ( 23128233)
Interacting Genes		10 interacting genes: AQP6 CHM ELOVL4 ERRFI1 FAM107A PDE6D PPP2R1A PPP2R1B TAX1BP1 TOM1L1	4 interacting genes: CRHBP CRHR1 CRHR2 LEP
Entrez ID		22931	7349
HPRD ID		03731	02970
Ensembl ID		ENSG00000099246	ENSG00000163794
Uniprot IDs		A0A087X163 B7Z4P9 B7Z5V3 Q9NP72	P55089
PDB IDs		1X3S	2RMF 3N96 6PB0 6PB1
Enriched GO Terms of Interacting Partners?
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