MMRN1 and F5

Data Source:
HPRD (in vitro)

		MMRN1	F5
Description		multimerin 1	coagulation factor V
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix	Golgi Membrane Extracellular Region Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Copper Ion Binding Protein Binding
	Biological Process	Platelet Degranulation Cell Adhesion Blood Coagulation	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Blood Circulation Post-translational Protein Modification Cellular Protein Metabolic Process COPII Vesicle Coating
Pathways		Platelet degranulation	Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation
Drugs			Drotrecogin alfa Thrombomodulin Alfa Thrombin Protein C Human thrombin Thrombin alfa Protein S human Anti-inhibitor coagulant complex
Diseases			Inherited thrombophilia Factor V deficiency; Owren disease
GWAS		Bitter alcoholic beverage consumption ( 31046077) Parkinson's disease ( 19915575)	Activated partial thromboplastin time ( 22703881 29403010) Blood protein levels ( 29875488 28240269) Cytokine network levels (multivariate analysis) ( 31679650) D-dimer levels ( 21502573) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Inflammatory biomarkers (multivariate analysis) ( 33110245) Ischemic stroke ( 26732560) Medication use (antithrombotic agents) ( 31015401) Optic disc area ( 25631615 31798171) Optic disc size ( 31809533) Peripheral artery disease ( 31285632) Plasma factor V levels in venous thrombosis ( 31271701) Prothrombin time ( 29403010) Stem cell growth factor beta levels ( 27989323) Thrombosis ( 26908601) Uric acid levels ( 23703922) Venous thromboembolism ( 21980494 23650146 25772935 32232851 28373160 31420334 22672568 31676865) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		2 interacting genes: CDKN2A F5	11 interacting genes: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3 SRPK2
Entrez ID		22915	2153
HPRD ID		03267	01964
Ensembl ID		ENSG00000138722	ENSG00000198734
Uniprot IDs		Q13201	P12259
PDB IDs			1CZS 1CZT 1CZV 1FV4 1Y61 3P6Z 3P70 3S9C
Enriched GO Terms of Interacting Partners?
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