FKBP4 and NR3C2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		FKBP4	NR3C2
Description		FKBP prolyl isomerase 4	nuclear receptor subfamily 3 group C member 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Microtubule Protein-containing Complex Neuronal Cell Body Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome	Chromatin Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Receptor Complex
	Molecular Function	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Copper-dependent Protein Binding Tau Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Protein Folding Copper Ion Transport Negative Regulation Of Neuron Projection Development Negative Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Chaperone-mediated Protein Folding Regulation Of Cellular Response To Heat	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS	HSP90 chaperone cycle for steroid hormone receptors (SHR) SUMOylation of intracellular receptors
Drugs			Nimodipine Progesterone Spironolactone Fluticasone propionate Testosterone Fludrocortisone Eplerenone Clobetasol propionate Felodipine Desoxycorticosterone pivalate Drospirenone Stanolone Metribolone Aldosterone Corticosterone Desoxycorticosterone acetate Fluticasone furoate Fluticasone Testosterone cypionate Testosterone enanthate Testosterone undecanoate Stanolone acetate
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Hypertension exacerbated in pregnancy
GWAS		Apolipoprotein A1 levels ( 32203549) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Quantitative traits ( 19197348)	Alzheimer disease and age of onset ( 26830138) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Biochemical measures ( 19260141) Blond vs. brown/black hair color ( 30531825) Central corneal thickness ( 32528159 29760442) Corneal structure ( 23291589) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hippocampal volume ( 31530798) Hypothyroidism ( 27182965) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Microalbuminuria ( 31511532) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Plasma thyroid-stimulating hormone levels ( 28333968) Platelet distribution width ( 32888494) Platelet reactivity in response to clopidogrel treatment ( 32472697) Subcutaneous adipose tissue ( 22589738) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Vestibular neuritis ( 30079052)
Interacting Genes		26 interacting genes: ACVR1 AHSA1 ATOX1 CALM1 CSNK2A1 EGFR ESR1 FES FKBP1A GLMN HSF1 HSP90AA1 HSPA4 IRF4 NR3C1 NR3C2 PHYH PTPN2 S100A1 S100A2 S100A6 SH3BP4 SMURF2 SNCA SQSTM1 STIP1	20 interacting genes: ACSL1 ACTA1 ACTG1 AR CASP8AP2 FKBP4 HSP90AA1 HSPA4 NCOA1 NR3C1 PIAS1 PIAS3 PROX1 PSMC5 PTGES3 RABAC1 RXRA SUMO1 TRIM24 UBE2I
Entrez ID		2288	4306
HPRD ID		11794	02991
Ensembl ID		ENSG00000004478	ENSG00000151623
Uniprot IDs		Q02790	B0ZBF6 P08235
PDB IDs		1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX 4LAY 4TW8 6RCY	1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG 4PF3 4TNT 4UDA 4UDB 5HCV 5L7E 5L7G 5L7H 5MWP 5MWY 6GEV 6GG8 6GGG 6L88
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?