SLC35F1 and GJA5

Data Source:
BioGRID (two hybrid)

		SLC35F1	GJA5
Description		solute carrier family 35 member F1	gap junction protein alpha 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Integral Component Of Plasma Membrane Gap Junction Connexin Complex Intercalated Disc Cell Projection
	Molecular Function	Protein Binding Transmembrane Transporter Activity	Gap Junction Channel Activity Protein Binding Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Disordered Domain Specific Binding
	Biological Process	Transmembrane Transport	Angiogenesis Negative Regulation Of Glomerular Filtration Outflow Tract Morphogenesis Endothelium Development Mitral Valve Development Pulmonary Valve Formation Ventricular Septum Development Atrial Septum Development Potassium Ion Transport Cell-cell Signaling Cell Communication By Chemical Coupling Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Gap Junction Assembly Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Artery Morphogenesis Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of AV Node Cell Action Potential Regulation Of Bundle Of His Cell Action Potential Regulation Of Purkinje Myocyte Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Vasomotion
Pathways			Gap junction assembly
Drugs
Diseases			Atrial fibrillation
GWAS		Atrial fibrillation ( 28416818 30061737 29892015) Cardiac structure and function ( 19584346) Diastolic blood pressure ( 28135244 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Heart rate ( 23583979) PR interval ( 32439900) QRS duration ( 30679814 27659466) QT interval ( 30679814 29213071 24952745 19305408 19587794 29874175) Resting heart rate ( 20639392) Systolic blood pressure ( 27841878) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) TPE interval (resting) ( 32386560)	Atrial fibrillation ( 30061737 29892015) Cognitive performance ( 20125193) Methotrexate-induced interstitial lung disease in rheumatoid arthritis ( 28500057) PR interval ( 32439900)
Interacting Genes		7 interacting genes: AQP6 COMT GJA5 GJA8 SLC35C2 TMEM14B TRARG1	34 interacting genes: AAR2 ABHD16A BLCAP C4orf3 EMP3 FCER1G GJA1 GJB2 IGFBP5 LEPROT LEPROTL1 LHFPL2 MARK1 MFSD5 MS4A13 NIPAL3 NKG7 PGAP2 PRAF2 PRKACA RIMS3 RPRM SLC13A4 SLC30A2 SLC35F1 SLC41A1 SLC41A2 SLC66A1 TMBIM6 TMEM107 TREX1 UBQLN4 VRK2 YIPF6
Entrez ID		222553	2702
HPRD ID		18751	08699
Ensembl ID		ENSG00000196376	ENSG00000265107
Uniprot IDs		Q5T1Q4	P36382 X5D2H9
PDB IDs
Enriched GO Terms of Interacting Partners?
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