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BEND7 and PSMF1
Data Source:
HPRD
(two hybrid)
BEND7
PSMF1
Description
BEN domain containing 7
proteasome inhibitor subunit 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Exosome
Nucleoplasm
Endoplasmic Reticulum
Cytosol
Proteasome Core Complex
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Endopeptidase Inhibitor Activity
Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Proteasome Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Diastolic blood pressure (
30224653
)
Free thyroxine concentration (
30367059
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
PR interval (
32439900
)
Skin pigmentation (
28300201
)
Smoking status (ever vs never smokers) (
30643258
)
White blood cell count (
32888494
)
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Logical memory (immediate recall) in Alzheimer's disease dementia (
29274321
)
Interacting Genes
73 interacting genes:
ANP32B
BANF2
BYSL
C14orf119
CDC37
CDCA7L
CEP44
CHD2
CIB3
CSNK2A1
DDX6
DVL2
DVL3
EAF1
EAF2
EIF1AD
EMD
FAM124A
FAM133A
GADD45G
GEMIN2
GTPBP3
GYS1
HMBOX1
HSF2BP
KANK2
L3MBTL2
LMO3
LNX1
LYAR
MAGOHB
MFAP1
MLX
MORF4L1
MORF4L2
MYO15B
NAP1L3
NEK6
NIF3L1
NKAPD1
NOL12
NUTF2
OSGIN1
PBLD
PIM1
PLEKHF2
POLR3GL
PPIG
PPP1R37
PRMT3
PRPF40A
PSMB1
PSMF1
RAB29
RBM10
RIPPLY1
RPL22
SCNM1
SDCBP
SDCBP2
SMARCA2
SPANXN2
THAP1
TLK1
TNPO2
TRIM26
U2AF2
UBL5
USP20
VCX2
WHRN
ZCCHC10
ZNF622
36 interacting genes:
BEND7
CCDC85B
CD2BP2
CRX
CTBP2
DVL2
DVL3
GATA1
HOOK2
IKZF3
KHDRBS2
KHDRBS3
LDOC1
LNX1
LNX2
MAGEA11
MAGED1
MIEF2
NUDT21
PAK5
PDLIM7
PSMA7
QKI
RAB33A
RALYL
RBFOX1
RBFOX2
RBMX
RBPMS
RHOXF2
RNF126
TENT5B
TLE5
TRAF2
TRIM73
WWP2
Entrez ID
222389
9491
HPRD ID
12570
17919
Ensembl ID
ENSG00000165626
ENSG00000125818
Uniprot IDs
Q8N7W2
A0A140VJT2
B4DXW9
Q5QPM7
Q92530
PDB IDs
2VT8
4OUH
Enriched GO Terms of Interacting Partners
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