ZUP1 and RPS21

Data Source:
BioGRID (two hybrid)

		ZUP1	RPS21
Description		zinc finger containing ubiquitin peptidase 1	ribosomal protein S21
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Rough Endoplasmic Reticulum Cytosol Small Ribosomal Subunit Cytosolic Small Ribosomal Subunit Polysomal Ribosome
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Protein N-terminus Binding
	Biological Process	Proteolysis Regulation Of Gene Expression Protein Phosphopantetheinylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Colorectal cancer ( 26965516) Colorectal cancer or advanced adenoma ( 30510241) Prostate cancer ( 23535732)
Interacting Genes		8 interacting genes: ARHGAP45 CDKN2A CLN8 MMP14 PRMT5 RPS21 SHCBP1 UBC	8 interacting genes: APP CDC42 FHL5 LBP PLEKHF2 RPSA ZNF76 ZUP1
Entrez ID		221302	6227
HPRD ID		12840	01605
Ensembl ID		ENSG00000153975	ENSG00000171858
Uniprot IDs		A0A0S2Z644 Q96AP4	P63220 Q6FGH5
PDB IDs		6EI1 6FGE	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6G18 6G4S 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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