ALKBH3 and OTUD4

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ALKBH3	OTUD4
Description		alkB homolog 3, alpha-ketoglutarate dependent dioxygenase	OTU deubiquitinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol	Nucleus Cytosol
	Molecular Function	Protein Binding Ferrous Iron Binding L-ascorbic Acid Binding DNA-N1-methyladenine Dioxygenase Activity RNA N1-methyladenosine Dioxygenase Activity	RNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Molecular Adaptor Activity Lys63-specific Deubiquitinase Activity
	Biological Process	DNA Repair DNA Dealkylation Involved In DNA Repair Cell Population Proliferation Oxidative Single-stranded DNA Demethylation Oxidative Single-stranded RNA Demethylation	Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Toll-like Receptor Signaling Pathway Innate Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of DNA Demethylation Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		ALKBH3 mediated reversal of alkylation damage
Drugs		Ascorbic acid
Diseases
GWAS		Chronotype ( 30696823) Morning person ( 30696823)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412) Lung function (FEV1) ( 30061609) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 31628463) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: AK8 FBXO7 GLRX3 GOLGA2 IKZF1 LNX1 OTUD4 SRPK1 SRPK2 TRIM55 TRIM63 ZDHHC17	10 interacting genes: ALKBH3 EXOSC8 MAVS REL STAT1 TCF4 UBC USP7 VDR ZNF655
Entrez ID		221120	54726
HPRD ID		16793	11033
Ensembl ID		ENSG00000166199	ENSG00000164164
Uniprot IDs		Q96Q83	Q01804
PDB IDs		2IUW
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?