MS4A2 and FCER1A

Data Source:
HPRD (in vivo)

		MS4A2	FCER1A
Description		membrane spanning 4-domains A2	Fc fragment of IgE receptor Ia
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Fc-epsilon Receptor I Complex	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Protein Binding IgE Binding	Transmembrane Signaling Receptor Activity Protein Binding IgE Binding
	Biological Process	Inflammatory Response Immune Response Fc-epsilon Receptor Signaling Pathway	Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune Response
Pathways		Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation	Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation
Drugs		Omalizumab	Omalizumab Benzylpenicilloyl polylysine TNX-901
Diseases		Asthma
GWAS		Alzheimer's disease ( 31473137)	C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Select biomarker traits ( 17903293) White blood cell count ( 27863252)
Interacting Genes		11 interacting genes: AKT1 APP FCER1A GRB2 HSP90AA1 LYN PRKCD PTPN11 PTPN6 SYK TMEM86A	6 interacting genes: FCER1G ITIH2 LMNA MESD MS4A2 PDHB
Entrez ID		2206	2205
HPRD ID		00915	00917
Ensembl ID		ENSG00000149534	ENSG00000179639
Uniprot IDs		A0A0B4J2E9 Q01362	P12319
PDB IDs			1ALS 1ALT 1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q
Enriched GO Terms of Interacting Partners?
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