FASN and NDRG1

Data Source:
HPRD (in vivo)

		FASN	NDRG1
Description		fatty acid synthase	N-myc downstream regulated 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Exosome	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse
	Molecular Function	RNA Binding [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity 3-hydroxypalmitoyl-[acyl-carrier-protein] Dehydratase Activity Oleoyl-[acyl-carrier-protein] Hydrolase Activity Protein Binding (3R)-hydroxymyristoyl-[acyl-carrier-protein] Dehydratase Activity 3-hydroxydecanoyl-[acyl-carrier-protein] Dehydratase Activity Myristoyl-[acyl-carrier-protein] Hydrolase Activity Palmitoyl-[acyl-carrier-protein] Hydrolase Activity Phosphopantetheine Binding Identical Protein Binding Cadherin Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH, A-specific) Activity 3-hydroxyoctanoyl-[acyl-carrier-protein] Dehydratase Activity 3-oxo-glutaryl-[acp] Methyl Ester Reductase Activity 3-oxo-pimeloyl-[acp] Methyl Ester Reductase Activity	Protein Binding Microtubule Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding
	Biological Process	Osteoblast Differentiation Glandular Epithelial Cell Development Acetyl-CoA Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Ether Lipid Biosynthetic Process Neutrophil Differentiation Monocyte Differentiation Mammary Gland Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cholesterol Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Cellular Response To Interleukin-4 Establishment Of Endothelial Intestinal Barrier	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Regulation Of Apoptotic Process Mast Cell Activation Cellular Response To Hypoxia Postsynapse Organization
Pathways		ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs		Cerulenin Orlistat
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood protein levels ( 30072576) Major depressive disorder ( 27777418) Malate levels ( 31560688) Refractive error ( 32231278)	Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		11 interacting genes: ADIPOQ AKT1 DUX4 EWSR1 LNX1 MTDH NDRG1 PRR12 PTEN SUMO2 YWHAQ	70 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155
Entrez ID		2194	10397
HPRD ID		02567	05586
Ensembl ID		ENSG00000169710	ENSG00000104419
Uniprot IDs		P49327	B3KWB2 Q8N959 Q92597
PDB IDs		1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37 6NNA
Enriched GO Terms of Interacting Partners?
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