FANCC and CAPN10

Data Source:
BioGRID (two hybrid)

		FANCC	CAPN10
Description		FA complementation group C	calpain 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex	Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	Protein Binding	SNARE Binding Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Myeloid Cell Homeostasis DNA Repair Nucleotide-excision Repair Germ Cell Development Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Interstrand Cross-link Repair Brain Morphogenesis Protein-containing Complex Assembly Neuronal Stem Cell Population Maintenance	Proteolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Cytoskeleton Reorganization Positive Regulation Of Insulin Secretion Positive Regulation Of Intracellular Transport Cellular Response To Insulin Stimulus Positive Regulation Of Glucose Import Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Degradation of the extracellular matrix
Drugs
Diseases		Fanconi anemia	Type II diabetes mellitus
GWAS		Birth weight ( 31043758) Hematocrit ( 32888494) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 26284813)
Interacting Genes		54 interacting genes: APC AZIN1 BMPR1A BUB1 CAPN10 CCNA2 CCND1 CDK1 CTBP1 DLC1 DNAJB1 EGFR FANCA FANCD2 FANCE FANCF FANCG FBXW7 GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRAS KRT1 MEOX2 MLH3 MT-ATP6 MUTYH NRAS PDGFRL PIK3CA PMS2 POR PRDX3 PRPF31 PTPN12 PTPRJ RB1 RPL18 RPS3A SMAD4 SPTA1 SPTAN1 SRC STAT1 STMN1 STMN2 TCERG1 TGFBR2 USP14 ZBTB32	5 interacting genes: EFNB1 FANCC FLOT1 PSMA7 SHD
Entrez ID		2176	11132
HPRD ID		01967	05595
Ensembl ID		ENSG00000158169	ENSG00000142330
Uniprot IDs		A0A024R9N2 A0A087WW44 B4E3W2 Q00597	Q9HC96
PDB IDs
Enriched GO Terms of Interacting Partners?
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