F12 and MMP12

Data Source:
HPRD (in vivo)

		F12	MMP12
Description		coagulation factor XII	matrix metallopeptidase 12
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Misfolded Protein Binding	Core Promoter Sequence-specific DNA Binding Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Collagen Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Plasma Kallikrein-kinin Cascade Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Positive Regulation Of Plasminogen Activation Protein Processing Protein Autoprocessing Positive Regulation Of Blood Coagulation Zymogen Activation Fibrinolysis Innate Immune Response Response To Misfolded Protein Positive Regulation Of Fibrinolysis	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Protein Import Into Nucleus Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Interferon-alpha Production Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Regulation Of Defense Response To Virus By Host Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Elastin Catabolic Process Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Bronchiole Development Cellular Response To Virus Response To Amyloid-beta Negative Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin
Pathways		Intrinsic Pathway of Fibrin Clot Formation Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix
Drugs		Zinc Human C1-esterase inhibitor Ethanolamine oleate Conestat alfa Nafamostat Zinc acetate	Acetohydroxamic acid Marimastat CP-271485 PF-00356231 Batimastat 2-[2-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Ethyl]-4-(4'-Ethoxy-1,1'-Biphenyl-4-Yl)-4-Oxobutanoic Acid AE-941 (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE N-(biphenyl-4-ylsulfonyl)-D-leucine CGS-27023 N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide 2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide N-oxo-2-(phenylsulfonylamino)ethanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[(4-methoxyphenyl)sulfonyl]-D-alanine
Diseases		Factor XII deficiency; Hageman factor deficiency Hereditary angioedema
GWAS		Activated partial thromboplastin time ( 22703881 29403010 20303064) Blood metabolite ratios ( 24816252) Blood protein levels ( 29875488 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Nephrolithiasis ( 22396660) Platelet function and related traits ( 21546496) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alzheimer's disease ( 22832961) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Chronic obstructive pulmonary disease (severe) ( 24621683) Emphysema imaging phenotypes ( 26030696) Ischemic stroke ( 29531354) Ischemic stroke (large artery atherosclerosis) ( 29531354) Local histogram emphysema pattern ( 25006744) Peanut allergy ( 29030101) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Stroke ( 29531354)
Interacting Genes		16 interacting genes: APOH APP CD93 EPAS1 GP1BA HIF1A KLKB1 KRT1 MMP12 MMP13 MMP14 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N	5 interacting genes: APP F12 LPA PLAUR TFPI
Entrez ID		2161	4321
HPRD ID		01992	03027
Ensembl ID		ENSG00000131187	ENSG00000262406
Uniprot IDs		P00748 Q8IZZ5	P39900
PDB IDs		4BDW 4BDX 4XDE 4XE4 6B74 6B77 6GT6 6L63 6QF7 6SZW	1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 1YCM 1Z3J 2HU6 2JXY 2K2G 2K9C 2KRJ 2MLR 2MLS 2N8R 2OXU 2OXW 2OXZ 2POJ 2W0D 2WO8 2WO9 2WOA 2Z2D 3BA0 3EHX 3EHY 3F15 3F16 3F17 3F18 3F19 3F1A 3LIK 3LIL 3LIR 3LJG 3LK8 3LKA 3N2U 3N2V 3NX7 3RTS 3RTT 3TS4 3TSK 3UVC 4EFS 4GQL 4GR0 4GR3 4GR8 4GUY 4H30 4H49 4H76 4H84 4I03 4IJO 5CXA 5CZM 5D2B 5D3C 5I0L 5I2Z 5I3M 5I43 5I4O 5L79 5L7F 5LAB 5N5J 5N5K 6EKN 6ELA 6ENM 6EOX 6RD0 6RLY
Enriched GO Terms of Interacting Partners?
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