ALDH1A1 and PTPRF

Data Source:
BioGRID (affinity chromatography technology)

		ALDH1A1	PTPRF
Description		aldehyde dehydrogenase 1 family member A1	protein tyrosine phosphatase receptor type F
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome
	Molecular Function	Retinal Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity GTPase Activator Activity Androgen Binding Protein Binding Benzaldehyde Dehydrogenase (NAD+) Activity NAD Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding
	Biological Process	Retinoid Metabolic Process Ethanol Oxidation Cellular Aldehyde Metabolic Process Retinol Metabolic Process Positive Regulation Of GTPase Activity Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Negative Regulation Of Cold-induced Thermogenesis	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding
Pathways		RA biosynthesis pathway Fructose catabolism Ethanol oxidation	Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
Drugs		NADH Vitamin A Tretinoin 1,4-Dithiothreitol
Diseases
GWAS		Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Sensorimotor dexterity ( 31596458)	Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Stroke ( 29531354) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: ALDH2 BRCA1 NUPR1 POT1	59 interacting genes: ACAN ACAT1 ACTB ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB NCAN NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B TUBB4B VCAN ZNF512B
Entrez ID		216	5792
HPRD ID		00001	01552
Ensembl ID		ENSG00000165092	ENSG00000142949
Uniprot IDs		P00352 V9HW83	G1UI20 P10586
PDB IDs		4WB9 4WJ9 4WP7 4WPN 4X4L 5AC2 5L2M 5L2N 5L2O 5TEI 6DUM	1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW
Enriched GO Terms of Interacting Partners?
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