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F10 and PRKAB1
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
F10
PRKAB1
Description
coagulation factor X
protein kinase AMP-activated non-catalytic subunit beta 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Plasma Membrane
Intrinsic Component Of External Side Of Plasma Membrane
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleotide-activated Protein Kinase Complex
Molecular Function
Serine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Protein Kinase Activity
Protein Binding
Protein Kinase Binding
Biological Process
Proteolysis
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Blood Coagulation
Blood Coagulation, Extrinsic Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Kinase B Signaling
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Cell Cycle Arrest
Signal Transduction
Positive Regulation Of Gene Expression
Macroautophagy
Regulation Of Macroautophagy
Nail Development
Regulation Of Catalytic Activity
Regulation Of Primary Metabolic Process
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Defective factor IX causes thrombophilia
Defective cofactor function of FVIIIa variant
Defective F9 variant does not activate FX
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
Drugs
Antihemophilic factor, human recombinant
Coagulation factor VIIa Recombinant Human
Coagulation Factor IX (Recombinant)
Fondaparinux
Heparin
Enoxaparin
gamma-carboxy-L-glutamic acid
4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE
SSR-126517E
LY-517717
Rivaroxaban
Lanoteplase
Idraparinux
rNAPc2
Apixaban
Otamixaban
Eribaxaban
(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE
THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE
2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE
GW-813893
2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE
N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE
N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE
N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE
5-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H-1,2,4-TRIAZOLE-3-SULFONAMIDE
5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE
6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE
6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE
5-Chloro-N-{(3S)-1-[(2S)-1-(4-morpholinyl)-1-oxo-2-propanyl]-2-oxo-3-pyrrolidinyl}-1H-indole-2-sulfonamide
5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide
5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide
N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE
1-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE
5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE
5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE
5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE
THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE
3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE
4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE
4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE
4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE
1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE
Edoxaban
Turoctocog alfa
Protamine sulfate
Bemiparin
Kappadione
Antithrombin Alfa
Betrixaban
Nafamostat
Protein S human
Coagulation factor VII human
Anti-inhibitor coagulant complex
Coagulation Factor IX Human
Antihemophilic factor human
Albutrepenonacog alfa
Emicizumab
Nonacog beta pegol
Lonoctocog alfa
Moroctocog alfa
Turoctocog alfa pegol
Adenosine phosphate
Adenosine phosphate
Metformin
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Bipolar disorder (
31043756
)
Blood protein levels (
30072576
29875488
28240269
)
Factor VII (
17903294
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Basophil count (
32888494
)
Inflammatory bowel disease (
26192919
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil count (
32888494
)
Plateletcrit (
32888494
)
Ulcerative colitis (
26192919
)
White blood cell count (
32888494
)
Interacting Genes
21 interacting genes:
APOH
F3
F5
F7
F8
GAD2
GGCX
H1-2
MGST3
NBPF19
NOTCH2NLA
PLAT
PLG
PRKAB1
PROS1
SERPINA10
SERPINA5
SERPINB6
SERPINB8
TFPI
UBQLN2
12 interacting genes:
ACACA
AGL
APP
F10
GRB2
MAP3K7
MAPK6
NDUFA7
PRKAA1
PRKAA2
PRKAG1
PRKAG2
Entrez ID
2159
5564
HPRD ID
01966
04116
Ensembl ID
ENSG00000126218
ENSG00000111725
Uniprot IDs
P00742
Q5JVE7
Q5JVE8
A0A024RBN1
Q9Y478
PDB IDs
1C5M
1EZQ
1F0R
1F0S
1FAX
1FJS
1FXY
1G2L
1G2M
1HCG
1IOE
1IQE
1IQF
1IQG
1IQH
1IQI
1IQJ
1IQK
1IQL
1IQM
1IQN
1KSN
1LPG
1LPK
1LPZ
1LQD
1MQ5
1MQ6
1MSX
1NFU
1NFW
1NFX
1NFY
1NL8
1P0S
1V3X
1WU1
1XKA
1XKB
1Z6E
2BMG
2BOH
2BOK
2BQ6
2BQ7
2BQW
2CJI
2D1J
2EI6
2EI7
2EI8
2FZZ
2G00
2GD4
2H9E
2J2U
2J34
2J38
2J4I
2J94
2J95
2JKH
2P16
2P3F
2P3T
2P3U
2P93
2P94
2P95
2PHB
2PR3
2Q1J
2RA0
2UWL
2UWO
2UWP
2VH0
2VH6
2VVC
2VVU
2VVV
2VWL
2VWM
2VWN
2VWO
2W26
2W3I
2W3K
2WYG
2WYJ
2XBV
2XBW
2XBX
2XBY
2XC0
2XC4
2XC5
2Y5F
2Y5G
2Y5H
2Y7X
2Y7Z
2Y80
2Y81
2Y82
3CEN
3CS7
3ENS
3FFG
3HPT
3IIT
3K9X
3KL6
3KQB
3KQC
3KQD
3KQE
3LIW
3M36
3M37
3Q3K
3SW2
3TK5
3TK6
4A7I
4BTI
4BTT
4BTU
4Y6D
4Y71
4Y76
4Y79
4Y7A
4Y7B
4ZH8
4ZHA
5JQY
5JTC
5JZ8
5JZU
5K0H
5VOE
5VOF
6Q9F
6Q9I
6RK9
4CFE
4CFF
4ZHX
5EZV
5ISO
6B1U
6C9F
6C9G
6C9H
6C9J
Enriched GO Terms of Interacting Partners
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