F2RL2 and CTSG

Data Source:
HPRD (in vivo)

		F2RL2	CTSG
Description		coagulation factor II thrombin receptor like 2	cathepsin G
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Protein-containing Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Plasma Membrane Cell Surface Cytoplasmic Stress Granule Secretory Granule Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding Thrombin-activated Receptor Activity	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Blood Coagulation Response To Wounding Platelet Activation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Thrombin-activated Receptor Signaling Pathway	Angiotensin Maturation Protein Phosphorylation Proteolysis Immune Response Antimicrobial Humoral Response Antibacterial Humoral Response Extracellular Matrix Disassembly Neutrophil Degranulation Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Fungus Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection
Drugs			Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS		Mean platelet volume ( 28031487) Phenylephrine infusion rate during anesthesia ( 31455332)	Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)
Interacting Genes		8 interacting genes: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3	30 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1
Entrez ID		2151	1511
HPRD ID		03561	00289
Ensembl ID		ENSG00000164220	ENSG00000100448
Uniprot IDs		O00254	P08311
PDB IDs			1AU8 1CGH 1KYN 1T32 6VTM
Enriched GO Terms of Interacting Partners?
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