ALCAM and LAG3

Data Source:
HPRD (in vivo)

		ALCAM	LAG3
Description		activated leukocyte cell adhesion molecule	lymphocyte activating 3
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Axon Dendrite Intrinsic Component Of Plasma Membrane T Cell Receptor Complex Neuronal Cell Body Extracellular Exosome	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding
	Biological Process	Adaptive Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Motor Neuron Axon Guidance Retinal Ganglion Cell Axon Guidance Axon Extension Involved In Axon Guidance Neuron Projection Extension	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Interleukin-2 Production Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response
Pathways		L1CAM interactions	MHC class II antigen presentation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576 29875488) Body mass index ( 25673413) Breast cancer ( 31757997) Chronotype ( 30696823) Cortical surface area (visual PC2) ( 32198502) Erectile dysfunction in type 1 diabetes ( 22704111) Glomerular filtration rate in chronic kidney disease ( 26420894) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Initial pursuit acceleration ( 29064472) Intraocular pressure ( 29617998) Irritable mood ( 29500382) Metabolite levels ( 23823483) Ovarian disease with few adhesions ( 28333195) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Visceral fat ( 30942860)	Blood protein levels ( 30072576)
Interacting Genes		3 interacting genes: ART3 CD6 EGFR	2 interacting genes: CEBPZ CENPJ
Entrez ID		214	3902
HPRD ID		03389	01077
Ensembl ID		ENSG00000170017	ENSG00000089692
Uniprot IDs		B3KNN9 Q13740	P18627
PDB IDs		1KJC 5A2F
Enriched GO Terms of Interacting Partners?
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