EXT2 and GSKIP

Data Source:
BioGRID (two hybrid)

		EXT2	GSKIP
Description		exostosin glycosyltransferase 2	GSK3B interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Membrane UDP-N-acetylglucosamine Transferase Complex Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	Protein Binding Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity, Transferring Glycosyl Groups Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity	Protein Kinase Inhibitor Activity Protein Binding Beta-catenin Binding Kinase Regulator Activity Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
	Biological Process	Ossification Mesoderm Formation Glycosaminoglycan Biosynthetic Process Protein N-linked Glycosylation Signal Transduction Regulation Of Blood Pressure Gene Expression Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Cell Differentiation Heparin Biosynthetic Process Cellular Polysaccharide Biosynthetic Process Fluid Transport Vasodilation Cellular Response To Fibroblast Growth Factor Stimulus Multicellular Organismal Water Homeostasis Sulfation Sodium Ion Homeostasis Heart Contraction Endochondral Bone Morphogenesis	Negative Regulation Of Protein Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Drugs
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses Multiple exostoses
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Refractive error ( 32231278)	Conotruncal heart defects (inherited effects) ( 28468790)
Interacting Genes		10 interacting genes: ANXA7 CDKN1A EXT1 GALNT5 GSKIP PFDN1 SLC22A2 SMN1 TK1 TRAP1	3 interacting genes: EXT2 GSK3A PEX19
Entrez ID		2132	51527
HPRD ID		00599	16601
Ensembl ID		ENSG00000151348	ENSG00000100744
Uniprot IDs		D3DR24 Q93063	A0A024R6P6 Q9P0R6
PDB IDs			1SGO
Enriched GO Terms of Interacting Partners?
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