EWSR1 and SF3B4

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		EWSR1	SF3B4
Description		EWS RNA binding protein 1	splicing factor 3b subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Nucleolus U2-type Precatalytic Spliceosome
	Molecular Function	Transcription Coregulator Activity RNA Binding Protein Binding Calmodulin Binding Identical Protein Binding Metal Ion Binding	RNA Binding Protein Binding Splicing Factor Binding
	Biological Process	Regulation Of Transcription, DNA-templated	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways			mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases		Ewing's sarcoma Myxoid liposarcoma Clear cell sarcoma of soft tissue Extraskeletal myxoid chondrosarcoma
GWAS		Breast cancer ( 23535729) Pancreatic cancer ( 25086665) Platelet count ( 27863252) Platelet distribution width ( 32888494)	Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth length ( 25281659) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 20881960 31562340 18391951) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		162 interacting genes: ACTL6A AGT ANXA11 ARID1A ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BRME1 BTK C11orf16 CALM1 CCDC7 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EPAS1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 H2BC15 HBP1 HDAC3 HERPUD1 HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRMT8 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SELENOI SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SMARCC1 SMARCC2 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383	104 interacting genes: APBB1 BAG3 BAIAP2 BMPR1A CHERP CWF19L2 DDX17 DDX42 EFTUD2 EWSR1 FKBP1A FRK GRB2 HNRNPD HNRNPF HNRNPH1 HNRNPUL1 HSPB7 ILF3 ITSN1 MAPK9 METTL17 MIR1-1 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20B MIR21 MIR221 MIR222 MIR25 MIR29A MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-3 MIR9-1 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I NCK2 NUB1 PPP1R16B PRPF40A QARS1 RAMAC RBM10 RBM39 RBM4 RPP25 SEC24D SF1 SF3B2 SRSF6 SS18L1 STK19 SUMO4 TCAF1 TCERG1 TFG TLE5 TRAF4 U2AF2 UBASH3A WBP4 WDR77 ZCCHC10 ZNF3 ZNF48
Entrez ID		2130	10262
HPRD ID		00592	12028
Ensembl ID		ENSG00000182944	ENSG00000143368
Uniprot IDs		Q01844	B3KUJ0 Q15427
PDB IDs		2CPE	1X5T 5GVQ 5Z56 5Z57 5Z58 6AH0 6QX9 6Y53 6Y5Q
Enriched GO Terms of Interacting Partners?
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