ESRRB and HSP90AB1

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ESRRB	HSP90AB1
Description		estrogen related receptor beta	heat shock protein 90 alpha family class B member 1
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GO Annotations	Cellular Component	Chromatin Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Cytosol Integrator Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane COP9 Signalosome Membrane Inclusion Body Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Protein-containing Complex Aryl Hydrocarbon Receptor Complex Secretory Granule Lumen Melanosome Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen HSP90-CDC37 Chaperone Complex Sperm Head Plasma Membrane Ooplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Transcription Factor Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	UTP Binding CTP Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding GTP Binding Drug Binding Sulfonylurea Receptor Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding DATP Binding Peptide Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding ATP-dependent Protein Binding Protein Folding Chaperone Ion Channel Binding Cadherin Binding Protein Dimerization Activity Tau Protein Binding Unfolded Protein Binding DNA Polymerase Binding Disordered Domain Specific Binding Histone Methyltransferase Binding
	Biological Process	Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Stem Cell Division Stem Cell Population Maintenance Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Cell Dedifferentiation Photoreceptor Cell Maintenance Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Involved In G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division Negative Regulation Of Stem Cell Differentiation	Placenta Development Protein Folding Xenobiotic Metabolic Process Response To Unfolded Protein Telomere Maintenance Via Telomerase Response To Salt Stress Virion Attachment To Host Cell Central Nervous System Neuron Axonogenesis Establishment Of Cell Polarity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Heat Cellular Response To Drug Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Cocaine Positive Regulation Of Protein Import Into Nucleus Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Size Axon Extension Protein Stabilization Chaperone-mediated Protein Complex Assembly Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Telomerase Activity Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Cell Cycle Arrest Cellular Response To Interleukin-4 Cellular Response To Organic Cyclic Compound Positive Regulation Of Protein Serine/threonine Kinase Activity Supramolecular Fiber Organization Regulation Of Cellular Response To Heat Negative Regulation Of Transforming Growth Factor Beta Activation Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Tau-protein Kinase Activity Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Cellular Protein Localization Positive Regulation Of Cyclin-dependent Protein Kinase Activity Telomerase Holoenzyme Complex Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		Nuclear Receptor transcription pathway	Regulation of actin dynamics for phagocytic cup formation HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase HSF1-dependent transactivation Sema3A PAK dependent Axon repulsion Uptake and function of diphtheria toxin Neutrophil degranulation The NLRP3 inflammasome The role of GTSE1 in G2/M progression after G2 checkpoint Aryl hydrocarbon receptor signalling ESR-mediated signaling RHOBTB2 GTPase cycle Estrogen-dependent gene expression Chaperone Mediated Autophagy Purinergic signaling in leishmaniasis infection Potential therapeutics for SARS
Drugs		Diethylstilbestrol Genistein Flavone	Geldanamycin 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Radicicol Tanespimycin SNX-5422 CCT-018159 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Polaprezinc
Diseases
GWAS		Maximal oxygen uptake response ( 25729143) Sphingomyelin 24:0 levels ( 31560688) Tuberculosis ( 30287856)	Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: ESRRG HIF1A HSP90AA1 HSP90AB1 NCOA2 NCOA3 NRIP1 SP1	59 interacting genes: ACD AKT1 ARHGAP1 CCT2 CDC37L1 CDKN2A CHORDC1 CHUK CLIC4 CSNK2A1 CYP17A1 DDX24 EGFR ENO1 ESR1 ESRRB FCHSD2 GABARAPL1 GABARAPL2 HSF1 HSPB1 IKBKB IKBKE IKBKG ITGB1BP2 KEAP1 MAP3K14 MAP3K3 MAPK6 MAST1 MKNK1 NR2C2 NR3C1 NR4A1 POT1 PPID PTEN PTGES3 RHOBTB2 SERPINB5 SGTA SIRPA SLC34A1 STARD13 STAT1 STAT3 SUMO2 TAF1D TBK1 TERF1 TINF2 TNNT1 TP53 TSSK6 UBE3A UNC45A USP50 WASL YWHAB
Entrez ID		2103	3326
HPRD ID		03700	06763
Ensembl ID		ENSG00000119715	ENSG00000096384
Uniprot IDs		O95718	A0A024RD80 B4DGL0 P08238 Q6PK50
PDB IDs		1LO1 6LIT 6LN4	1QZ2 1UYM 2L6J 3FWV 3NMQ 3PRY 3UQ3 5FWK 5FWL 5FWM 5FWP 5UC4 5UCH 5UCI 5UCJ 6N8W 6N8Y
Enriched GO Terms of Interacting Partners?
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