ERCC4 and XPA

Data Source:
BioGRID (pull down)

		ERCC4	XPA
Description		ERCC excision repair 4, endonuclease catalytic subunit	XPA, DNA damage recognition and repair factor
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm ERCC4-ERCC1 Complex	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Intercellular Bridge
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding Telomerase Inhibitor Activity Identical Protein Binding Protein N-terminus Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Via Nonhomologous End Joining Response To UV UV Protection Regulation Of Autophagy Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Cellular Response To UV Interstrand Cross-link Repair Negative Regulation Of Telomerase Activity Telomeric DNA-containing Double Minutes Formation Global Genome Nucleotide-excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protection From Non-homologous End Joining At Telomere Negative Regulation Of Double-stranded Telomeric DNA Binding	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion UV Protection Response To Auditory Stimulus Nucleotide-excision Repair, DNA Incision Protein Localization To Nucleus Global Genome Nucleotide-excision Repair UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Bilirubin levels ( 22085899) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Bitter alcoholic beverage consumption ( 31046077) Bone mineral density (total hip) ( 29883787) Conduct disorder (symptom count) ( 20585324) Egg allergy ( 25710614) Emphysema imaging phenotypes ( 26030696) Metabolic syndrome ( 20694148) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 31170924)	Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		13 interacting genes: ERCC1 FANCG GTF2H1 KIF11 RAD52 RPA1 RPA2 SLX1A SLX4 SPTAN1 SUMO2 TACC1 XPA	51 interacting genes: ARID3A ATM ATR AURKA BMPR1A BUB1 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC4 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655
Entrez ID		2072	7507
HPRD ID		00594	02045
Ensembl ID		ENSG00000175595	ENSG00000136936
Uniprot IDs		A0A1W1GSK9 B4DXD8 Q92889	P23025
PDB IDs		1Z00 2A1J 2AQ0 2KN7 2MUT 6SXA 6SXB	1D4U 1XPA 2JNW 6J44 6LAE 6RO4
Enriched GO Terms of Interacting Partners?
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