DHRSX and FADS3

Data Source:
BioGRID (two hybrid)

		DHRSX	FADS3
Description		dehydrogenase/reductase X-linked	fatty acid desaturase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Oxidoreductase Activity	Molecular_function Protein Binding Oxidoreductase Activity
	Biological Process	Positive Regulation Of Autophagy	Unsaturated Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process
Pathways
Drugs
Diseases
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma (adult onset) ( 31036433) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Cholesterol, total ( 24097068 19060911 25961943 20686565) Fatty acid desaturase activity (serum) ( 30453627) Glycerophospholipid levels ( 26068415) HDL cholesterol ( 24097068 19060906 19060911 25961943 20686565) HDL cholesterol levels ( 28334899) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 24097068 19060911 25961943 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 23823483 23378610 22916037) Oleic acid (18:1n-9) levels ( 23362303) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30423114 24390342) Serum metabolite levels (CMS) ( 31636271) Sphingolipid d18:1/d18:2 ratio ( 31862735) Sphingolipid levels ( 19798445 26068415 22359512) Stearic acid (18:0) levels ( 23362303) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 24097068 19060906 25961943 20686565) Urate levels ( 31578528)
Interacting Genes		20 interacting genes: APOC1 APP AQP6 ASPH ATXN1 CIDEB CMTM5 FADS3 GCNT3 HSD17B11 PGRMC2 PIGP RETREG3 RUSF1 TLCD4 TMEM143 TMEM14B TMEM31 TMEM86B ZDHHC15	1 interacting genes: DHRSX
Entrez ID		207063	3995
HPRD ID		16803	07547
Ensembl ID		ENSG00000169084	ENSG00000221968
Uniprot IDs		Q8N5I4	A0A024R564 Q9Y5Q0
PDB IDs
Enriched GO Terms of Interacting Partners?
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