CLN8 and SPCS2

Data Source:
BioGRID (two hybrid)

		CLN8	SPCS2
Description		CLN8 transmembrane ER and ERGIC protein	signal peptidase complex subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Presynapse	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ceramide Binding	Peptidase Activity
	Biological Process	Age-dependent Response To Oxidative Stress Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Regulation Of Cell Size Lipid Biosynthetic Process Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Apoptotic Process Cellular Protein Catabolic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Glutamate Reuptake Lipid Homeostasis Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization	Signal Peptide Processing Protein Targeting To ER
Pathways			SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases		Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		30 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 FZD7 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUP1	5 interacting genes: ATP13A2 CLN8 EGFR STMN3 TEFM
Entrez ID		2055	9789
HPRD ID		06383	15435
Ensembl ID		ENSG00000182372	ENSG00000118363
Uniprot IDs		A0A024QZ57 Q9UBY8	Q15005
PDB IDs
Enriched GO Terms of Interacting Partners?
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