STOM and ASIC2

Data Source:
HPRD (in vivo)

		STOM	ASIC2
Description		stomatin	acid sensing ion channel subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Endoplasmic Reticulum Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Vesicle Azurophil Granule Membrane Specific Granule Membrane Melanosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Membrane Blood Microparticle	Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Dendritic Spine
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity RNA Polymerase Binding	Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity
	Biological Process	Neutrophil Degranulation Positive Regulation By Host Of Viral Genome Replication Positive Regulation Of Protein Targeting To Membrane Regulation Of Acid-sensing Ion Channel Activity	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Chemical Synaptic Transmission Central Nervous System Development Peripheral Nervous System Development Phototransduction Sensory Perception Of Sound Response To Acidic PH Regulation Of Vasoconstriction Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Positive Regulation Of Synapse Assembly Inorganic Cation Transmembrane Transport
Pathways		Stimuli-sensing channels Neutrophil degranulation	Stimuli-sensing channels
Drugs			Amiloride
Diseases		Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS			Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 26912274) Mosquito bite size ( 28199695) Plasma parathyroid hormone levels ( 30134803) Polycystic ovary syndrome ( 30343302) Serum bilirubin levels in metabolic syndrome ( 30621171) Severe gingival inflammation ( 28459102)
Interacting Genes		81 interacting genes: AIG1 APOA2 ASIC1 ASIC2 ASIC3 ATP1B3 ATP6V0B ATP6V0C BCL2L2 BNIP1 C2 C3orf52 CFHR5 CHST1 CLDN19 CLRN2 CMTM5 CNIH3 CTXN3 CYB5B CYB5R3 DAGLA DVL3 EMP1 ERG28 FAXDC2 FUNDC2 GIMAP1 GIMAP5 GPR25 GPR37L1 GRM2 HMOX2 KCNK1 KTN1 LANCL1 LNPEP MGLL MMP14 NKG7 ORMDL1 PEDS1-UBE2V1 PEMT PGA4 PMP22 PTCH1 RPL13A RPRM RTP2 RUVBL1 RUVBL2 SCD SELENOK SERP2 SFT2D1 SFT2D2 SFXN1 SFXN5 SLC2A1 SLC35B4 SMCO4 STX6 TECR THSD7B TMEM109 TMEM120B TMEM140 TMEM14B TMEM203 TMEM208 TMEM254 TMEM60 TMEM86B TMEM98 TMPO TNF TNFRSF10C TSPO2 VAMP4 WFDC2 YIPF6	4 interacting genes: ASIC1 ASIC3 PICK1 STOM
Entrez ID		2040	40
HPRD ID		00585	03471
Ensembl ID		ENSG00000148175	ENSG00000108684
Uniprot IDs		A0A024R882 F8VSL7 P27105	Q16515
PDB IDs			6L6P
Enriched GO Terms of Interacting Partners?
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