CENPX and FANCM

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		CENPX	FANCM
Description		centromere protein X	FA complementation group M
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GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleoplasm Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Nucleoplasm Fanconi Anaemia Nuclear Complex FANCM-MHF Complex
	Molecular Function	DNA Binding Double-stranded DNA Binding Protein Binding	Four-way Junction DNA Binding Chromatin Binding RNA Helicase Activity Nuclease Activity Protein Binding ATP Binding Four-way Junction Helicase Activity 3'-5' DNA Helicase Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Replication Fork Processing Positive Regulation Of Protein Ubiquitination CENP-A Containing Nucleosome Assembly Interstrand Cross-link Repair Cell Division Kinetochore Assembly	Resolution Of Meiotic Recombination Intermediates Replication Fork Processing DNA Duplex Unwinding Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Replication Fork Reversal Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Protein Monoubiquitination
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere Fanconi Anemia Pathway	Fanconi Anemia Pathway
Drugs
Diseases			Fanconi anemia
GWAS			Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		7 interacting genes: CENPS FANCM NKX3-1 REL TP53 TRIM54 UBE2I	11 interacting genes: APP CENPX ECT2 EME2 EPN2 FAAP24 LRRK2 RMI1 RMI2 TRIM27 UBE2I
Entrez ID		201254	57697
HPRD ID		18121	13876
Ensembl ID		ENSG00000169689	ENSG00000187790
Uniprot IDs		A8MT69 J3QRS1	Q8IYD8
PDB IDs		4DRA 4DRB 4E44 4E45 4NDY 4NE1 4NE3 4NE5 4NE6	4BXO 4DAY 4DRB 4E45 4M6W
Enriched GO Terms of Interacting Partners?
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