FLCN and CCDC180

Data Source:
BioGRID (two hybrid)

		FLCN	CCDC180
Description		folliculin	coiled-coil domain containing 180
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Centrosome Cytosol Plasma Membrane Cilium Midbody Cell-cell Contact Zone Mitotic Spindle	Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell-cell Junction Assembly Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrion Organization Hemopoiesis Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Lysosome Localization Regulation Of Cytokinesis Cellular Response To Amino Acid Starvation Negative Regulation Of Rho Protein Signal Transduction Regulation Of Histone Acetylation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Energy Homeostasis Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of TORC1 Signaling Regulation Of Pro-B Cell Differentiation Negative Regulation Of ATP Biosynthetic Process
Pathways		Amino acids regulate mTORC1
Drugs
Diseases		Renal cell carcinoma Birt-Hogg-Dube syndrome
GWAS		Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494)
Interacting Genes		11 interacting genes: ALDOB APP CCDC180 FBP1 GABARAP HEMGN HSP90AA1 MAP1LC3B NANS TMEFF1 TSTD2	20 interacting genes: BCL10 BUB1 CDKN2A CTNNA1 DLC1 ERBB2 FLCN MCC MLH1 MLH3 MSH2 NRAS PDGFRL PMS2 PTEN PTPN12 RB1 SMAD4 SRC STK11
Entrez ID		201163	100499483
HPRD ID		06278
Ensembl ID		ENSG00000154803	ENSG00000197816
Uniprot IDs		A0A0S2Z5Y7 Q8NFG4	B4DZK1 Q9P1Z9
PDB IDs		3V42 6NZD 6ULG
Enriched GO Terms of Interacting Partners?
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