EIF2S3 and METAP2

Data Source:
HPRD (in vivo, in vitro)

		EIF2S3	METAP2
Description		eukaryotic translation initiation factor 2 subunit gamma	methionyl aminopeptidase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	TRNA Binding Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Cadherin Binding	RNA Binding Aminopeptidase Activity Protein Binding Metalloexopeptidase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Formation Of Translation Preinitiation Complex Translational Initiation Positive Regulation Of Translational Fidelity Transmembrane Transport	Protein Processing Peptidyl-methionine Modification Regulation Of Rhodopsin Mediated Signaling Pathway N-terminal Protein Amino Acid Modification Protein Initiator Methionine Removal
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Guanosine-5'-Diphosphate	Methionine Nitroxoline 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium Fumagillin D-Methionine N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide (2R,3R,4S,5R,6E)-3,4,5-Trihydroxy-N-[(3S,6R)-6-hydroxy-2-oxo-3-azepanyl]-2-methoxy-8,8-dimethyl-6-nonenamide tert-butanol (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide Ovalicin PPI-2458 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID TNP-470
Diseases
GWAS		Prostate-specific antigen levels ( 28139693)	Blood protein levels ( 30072576) C-reactive protein levels ( 30388399) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252) Metabolite levels ( 23823483) Reticulocyte count ( 32888494)
Interacting Genes		2 interacting genes: METAP2 NDRG1	13 interacting genes: APP CALM1 CDC42 EIF2AK2 EIF2S3 FBXL17 HMGA1 MAPK1 MAPK3 PJA1 RAC1 S100A4 YWHAE
Entrez ID		1968	10988
HPRD ID		02155	03522
Ensembl ID		ENSG00000130741	ENSG00000111142
Uniprot IDs		P41091	A0A140VJE3 F8VQZ7 P50579
PDB IDs		6FEC 6K71 6K72 6O81 6O85 6YBV 6ZMW 6ZP4 7A09	1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ 5CLS 5D6E 5D6F 5JFR 5JHU 5JI6 5LYW 5LYX 6QED 6QEF 6QEG 6QEH 6QEI 6QEJ 7A12 7A13 7A14 7A15 7A16
Enriched GO Terms of Interacting Partners?
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