CELSR3 and SWAP70

Data Source:
HPRD (two hybrid)

		CELSR3	SWAP70
Description		cadherin EGF LAG seven-pass G-type receptor 3	switching B cell complex subunit SWAP70
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleus Cytoplasm Plasma Membrane Actin Cytoskeleton Lamellipodium
	Molecular Function	G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding	DNA Binding Calcium Ion Binding Protein Binding ATP Binding Cadherin Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Cell-cell Adhesion	Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Protein Localization Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Isotype Switching Actin Filament Bundle Assembly Positive Regulation Of Mast Cell Chemotaxis Negative Regulation Of Peptidyl-serine Dephosphorylation
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mental health study participation (provided email address) ( 31263887) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576 29875488) Coronary artery disease ( 32469254 29212778 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30224653 27841878 28739976 30487518) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertension ( 30487518) Ischemic stroke ( 29531354) Mean arterial pressure ( 29403010 30487518) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systolic blood pressure ( 27841878 30487518 30578418) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: CLK1 CLUH DST IFT140 SCAPER SGSM2 SPTBN2 SPTBN4 SWAP70 TRIP12 TSPYL4 UACA	5 interacting genes: CELSR3 IGHG1 PARP1 RAPGEF4 ZBTB5
Entrez ID		1951	23075
HPRD ID		09179	10378
Ensembl ID		ENSG00000008300	ENSG00000133789
Uniprot IDs		Q9NYQ7	B3KUB9 E7EMB1 Q9UH65
PDB IDs			2DN6
Enriched GO Terms of Interacting Partners?
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