EEF1A1 and ITSN1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EEF1A1	ITSN1
Description		eukaryotic translation elongation factor 1 alpha 1	intersectin 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Elongation Factor 1 Complex Plasma Membrane Membrane Cortical Actin Cytoskeleton Ruffle Membrane Secretory Granule Lumen Extracellular Exosome Cytoplasmic Side Of Lysosomal Membrane Ficolin-1-rich Granule Lumen	Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Lamellipodium Presynaptic Membrane Neuronal Cell Body Dendritic Spine Recycling Endosome Apical Dendrite Intracellular Vesicle Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse
	Molecular Function	TRNA Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding Calmodulin Binding GTP Binding Kinase Binding Protein Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Molecular Adaptor Activity Proline-rich Region Binding
	Biological Process	Translation Translational Elongation Neutrophil Degranulation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of D-erythro-sphingosine Kinase Activity Regulation Of Chaperone-mediated Autophagy	Exocytosis Endocytosis G Protein-coupled Receptor Signaling Pathway Brain Development Protein Transport Viral Process Endosomal Transport Cellular Protein Localization Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Ephrin Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Dendritic Spine Development Membrane Organization Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Eukaryotic Translation Elongation Eukaryotic Translation Elongation Peptide chain elongation HSF1 activation Neutrophil degranulation Protein methylation Chaperone Mediated Autophagy	NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Zinc Guanosine-5'-Diphosphate Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Bitter non-alcoholic beverage consumption ( 31046077) Educational attainment ( 25201988) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) QT interval ( 29213071) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252) Tonsillectomy ( 27182965 28928442)
Interacting Genes		130 interacting genes: ABTB2 ACTB ALPL ANKRD24 ANXA7 APLP1 AQP2 ARIH2 AXIN1 BBS1 BBS2 BBS4 BRMS1 BTBD2 CASP2 CCDC130 CCL18 CDC25A CDKN1A CKS2 COX17 CRADD CRCT1 CSRP2 DARS1 DIABLO DLEU1 DUSP7 DYNLL1 DYSF EIF3F EP300 EXOSC4 FAS GADD45A GADD45G HSPB2 HSPE1 HTRA2 IKBKG IMMT ITGB1BP1 ITSN1 KCNE3 KIF1B LAMA4 LAMTOR1 LAMTOR5 LSM3 MAD2L1BP MAGED2 MAP3K14 MAPK14 MLLT3 MNAT1 MRM1 MRPL42 MTRNR2L1 MYOC NEU1 NRAS NREP ORMDL3 PABPC4 PAEP PAFAH1B3 PAPSS1 PCDHA4 PFN2 PHYHIP PKN2 PLAUR PLCG1 POLE2 POLR2C PQBP1 PRKCD PSG9 PSMD11 PTPN4 PTPRCAP PTPRF RAB27A RAP2A RBBP8 RFC5 RGS12 RND1 RNF10 RPA2 RPLP1 RRAS RSRC1 SARS2 SDHAF2 SERPINB5 SERPINB9 SFN SHBG SMAD2 SMAD4 SMN1 SNCA SPP1 SSR1 STAT6 STMN2 SULT1E1 SUMO2 TAF9 TGIF1 TK1 TMPRSS3 TNFSF11 TP53BP2 TPT1 TRDMT1 TSPY1 TSPYL2 TTLL12 TTR UBQLN4 WARS1 XPO5 XRN2 YWHAG ZBTB16 ZCCHC10 ZNF24 ZPR1	87 interacting genes: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHO1 FCHO2 FCHSD2 FNBP1 FNBP4 GAREM2 GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAP3K20 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SGIP1 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 VLDLR WASL WBP11 ZFPM2
Entrez ID		1915	6453
HPRD ID		00559	03898
Ensembl ID		ENSG00000156508	ENSG00000205726
Uniprot IDs		P68104 Q6IPS9	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs		1SYW 3C5J 6ZMO	1KI1 2KGR 2KHN 3FIA 3QBV 4IIM 5HZI 5HZJ 5HZK 6GBU 6H5T
Enriched GO Terms of Interacting Partners?
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