DUSP4 and LYSMD2

Data Source:
BioGRID (two hybrid)

		DUSP4	LYSMD2
Description		dual specificity phosphatase 4	LysM domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity MAP Kinase Serine/threonine Phosphatase Activity
	Biological Process	Inactivation Of MAPK Activity Endoderm Formation Protein Dephosphorylation Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28598419) Postoperative complication after cardiac surgery ( 30678657) Response to statin therapy ( 20339536) Spontaneous preterm birth (maternal effect) ( 28598419)
Interacting Genes		19 interacting genes: APP CRMP1 GORASP2 GRIN1 GRIN2D LYSMD1 LYSMD2 LZTS2 MAPK1 MAPK14 MAPK3 MAPK8 MAPK9 NOXA1 PLEKHF2 TEPSIN TRAF1 ZNF426 ZNF655	3 interacting genes: CEP19 DUSP4 LCN9
Entrez ID		1846	256586
HPRD ID		04123	17531
Ensembl ID		ENSG00000120875	ENSG00000140280
Uniprot IDs		Q13115	Q8IV50
PDB IDs		3EZZ
Enriched GO Terms of Interacting Partners?
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