DRD5 and GNA12

Data Source:
HPRD (in vivo)

		DRD5	GNA12
Description		dopamine receptor D5	G protein subunit alpha 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium Brush Border Membrane Synapse Ciliary Membrane Non-motile Cilium	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Lateral Plasma Membrane Brush Border Membrane
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Associative Learning Transmission Of Nerve Impulse Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Response To Cocaine Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Female Receptivity Sensitization Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Reactive Oxygen Species Metabolic Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Fibroblast Migration Platelet Activation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Drug
Pathways		Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Lamotrigine Cinnarizine Lisuride Ergotamine Apomorphine Paroxetine Trimipramine Fenoldopam Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Methotrimeprazine Zuclopenthixol Rotigotine Mianserin Quinagolide Zotepine Dihydro-alpha-ergocryptine Epicriptine Pipradrol Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Impulsivity (motor) ( 30718321) Lung cancer ( 28604730) Manganese levels ( 26025379) Metabolite levels ( 23823483)	Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime sleep phenotypes ( 27126917) Eosinophil counts ( 32888494) Height ( 28552196 20881960 25282103 25429064 19343178 31562340 18391951 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Inflammatory bowel disease ( 28067908) Lateral ventricular volume in normal aging ( 30258056) Loneliness (linear analysis) ( 27629369) Monocyte count ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Subcortical volume (MOSTest) ( 32665545) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 28067908 23128233 21297633) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Weight ( 28552196) White matter integrity ( 23218918)
Interacting Genes		7 interacting genes: GABRG2 GNA12 GNA13 GNAZ NBPF19 NCS1 NOTCH2NLA	30 interacting genes: ACTB AGTR1 AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 S1PR4 S1PR5 TBXA2R TEC TSHR
Entrez ID		1816	2768
HPRD ID		00542	05093
Ensembl ID		ENSG00000169676	ENSG00000146535
Uniprot IDs		P21918	E9PC54 Q03113 Q6ZQV4
PDB IDs
Enriched GO Terms of Interacting Partners?
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