DRD1 and COPG1

Data Source:
HPRD (in vitro, in vivo)

		DRD1	COPG1
Description		dopamine receptor D1	COPI coat complex subunit gamma 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendritic Spine Ciliary Membrane Non-motile Cilium	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol COPI Vesicle Coat Transport Vesicle
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding	Structural Molecule Activity Protein Binding
	Biological Process	Synaptic Transmission, Dopaminergic G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Synapse Assembly Mating Behavior Adult Walking Behavior Visual Learning Positive Regulation Of Gene Expression Transmission Of Nerve Impulse Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Vasodilation Dopamine Metabolic Process Response To Drug Positive Regulation Of Potassium Ion Transport Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Cellular Response To Dopamine	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Secretion Establishment Of Golgi Localization Organelle Transport Along Microtubule
Pathways		Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Methylergometrine Clozapine Phenylpropanolamine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Periciazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Lumateperone Mianserin Asenapine Quinagolide Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pipradrol Tetrahydropalmatine Dihydrexidine Dihydroergocristine Aripiprazole lauroxil	S-(Dimethylarsenic)Cysteine
Diseases
GWAS		Cadmium levels ( 26025379) Chin dimples ( 27182965) Falling risk ( 32999390) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Treatment response for severe sepsis ( 22310353) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Height ( 31562340) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: ADA ADORA1 CALY CAV2 COPG1 COPG2 DNAJC14 DRD3 EPB41L2 FLNA GHSR GRIN1 HRH3 PDCD6IP PRKACA VPS35	19 interacting genes: ARCN1 ARF1 CDC42 COPB1 COPE COPG2 COPZ1 COPZ2 DRD1 H2AX PPBP PTGES3 RHOQ SACM1L SCYL1 SUMO2 TAPBP TMED10 WBP2
Entrez ID		1812	22820
HPRD ID		00538	09887
Ensembl ID		ENSG00000184845	ENSG00000181789
Uniprot IDs		P21728	Q9Y678
PDB IDs		1OZ5	1R4X
Enriched GO Terms of Interacting Partners?
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