DNMT3A and HDAC1

  • Data Source:
  • BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)
  • HPRD (in vivo, in vitro)

DNMT3A

HDAC1

Description DNA methyltransferase 3 alpha histone deacetylase 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Body mass index ( 26426971)
  • Body mass index (age <50) ( 26426971)
  • Body mass index (age>50) ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Body size at age 10 ( 32376654)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Crohn's disease ( 28067908 21102463)
  • Heel bone mineral density ( 30598549)
  • Height ( 28552196 25282103 25429064 31562340 18391951)
  • High light scatter reticulocyte count ( 32888494)
  • High light scatter reticulocyte percentage of red cells ( 32888494)
  • Inflammatory bowel disease ( 28067908)
  • Lymphocyte counts ( 32888494 27863252)
  • Lymphocyte percentage of white cells ( 32888494 27863252)
  • Macular thickness ( 30535121)
  • Monocyte count ( 32888494)
  • Multiple sclerosis ( 31604244)
  • Neutrophil percentage of white cells ( 32888494 27863252)
  • Resistant hypertension ( 31545351)
  • Type 1 diabetes ( 21980299)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for BMI in smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes 33 interacting genes: CBX1 DDB1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 H3C1 H3C6 HDAC1 MDFI MEOX2 MYC NRIP1 PIAS1 PIAS2 PRMT5 PTGES3 SETDB1 SP100 SPI1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18 ZNF513 189 interacting genes: APEX1 AR ARID4A ATF3 ATRX BAZ2A BCL11A BCL3 BCL6 BCL6B BCOR BHLHE40 BRCA1 BRMS1 BRMS1L BUB1 BUB1B BUB3 CBFA2T3 CCN5 CDC20 CDH1 CDKN1A CDYL CHD1 CHD4 CHFR CIITA CREBBP CREM CSNK2A1 CSNK2A2 CTBP1 CYTOR DAXX DDB2 DDX17 DHX30 DNMT1 DNMT3A DNMT3B DNMT3L EED EID2 EID2B ELK1 ENO1 EP300 ERCC6 EZH2 FKBP3 FOXG1 FRA10F GATA3 GCM1 GPS2 H2AC1 H3-4 H3C1 HBP1 HDAC2 HDAC3 HDAC7 HDAC9 HELLS HEY2 HIC1 HIF1A HIF1AN HNRNPD HR HUS1 IKZF1 ING1 IRF5 JDP2 KAT5 KCTD11 KDM1A KLF1 KLF11 KLF4 KLF5 LCOR MAD1L1 MAGEA1 MBD2 MBD3 MBD3L2 MBD4 MDM2 MECOM MECP2 MEN1 MIER1 MORF4L2 MTA1 MXD1 MYOD1 NCOR2 NFE4 NFKB1 NFKBIA NKX2-5 NKX3-2 NR1D2 NR2E3 NR2F2 NR3C1 NRIP1 NUP98 PARP1 PCNA PEX14 PHB PHB2 PHF12 PHF21A PIAS3 PIAS4 PITX2 PML PPARD PPARG PPP2R1B PRKACA PRKG1 PRRG4 PTMA RAD9A RAP1A RARA RB1 RBBP4 RBBP7 RBL1 RBL2 RBP1 RBPJ RELA REPIN1 RFC1 RFC4 RUNX1T1 RUNX3 RUVBL2 SALL1 SAP18 SAP30 SATB1 SATB2 SENP1 SERPINB5 SETDB1 SIN3A SIN3B SMAD2 SMAD3 SOX6 SP1 SP3 SPEN SPI1 STAT2 STAT3 SUDS3 SUMO2 SUV39H1 SYK TAB2 TAL1 TFCP2 TGIF1 TGIF2 THAP11 TNIP1 TOP2A TOP2B TP53 TPD52L1 TRIM27 TXNIP UBE2I USP38 USP43 VHL ZBTB16 ZMYND11 ZNF76
Entrez ID 1788 3065
HPRD ID 04141 03143
Ensembl ID ENSG00000119772 ENSG00000116478
Uniprot IDs A0A0C4DG02 F8WE91 Q59HC6 Q9Y6K1 Q13547 Q6IT96
PDB IDs 2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T 5YX2 6BRR 6F57 6PA7 6W89 6W8B 6W8D 6W8J 1TYI 4BKX 5ICN 6Z2J 6Z2K
Enriched GO Terms of Interacting Partners?
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