DNA2 and RBBP8

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DNA2	RBBP8
Description		DNA replication helicase/nuclease 2	RB binding protein 8, endonuclease
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Gamma DNA Polymerase Complex Mitochondrial Nucleoid	Nucleus Nucleoplasm Transcription Repressor Complex Site Of Double-strand Break Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Nuclease Activity Protein Binding ATP Binding ATPase Activity Site-specific Endodeoxyribonuclease Activity, Specific For Altered Base 5'-flap Endonuclease Activity Single-stranded DNA Helicase Activity 5'-3' DNA Helicase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Single-stranded DNA Endodeoxyribonuclease Activity Y-form DNA Binding Double-strand/single-strand DNA Junction Binding RNA Polymerase II Repressing Transcription Factor Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Protein Binding Identical Protein Binding Flap-structured DNA Binding
	Biological Process	DNA Replication Checkpoint Telomere Maintenance DNA Double-strand Break Processing DNA Replication Mitochondrial DNA Replication Base-excision Repair Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding DNA Replication, Okazaki Fragment Processing DNA Replication, Removal Of RNA Primer Mitochondrial DNA Repair G-quadruplex DNA Unwinding Positive Regulation Of DNA Replication Replication Fork Reversal Nucleic Acid Phosphodiester Bond Hydrolysis T-circle Formation Regulation Of Signal Transduction By P53 Class Mediator Mitotic Telomere Maintenance Via Semi-conservative Replication	Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Replication DNA Repair Regulation Of Transcription By RNA Polymerase II DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Negative Regulation Of Transcription, DNA-templated Cell Division Meiotic Cell Cycle Negative Regulation Of G0 To G1 Transition Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Removal of the Flap Intermediate from the C-strand HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation Removal of the Flap Intermediate G2/M DNA damage checkpoint	HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination
Drugs
Diseases			Seckel syndrome
GWAS			Eosinophil percentage of white cells ( 27863252) Height ( 25429064 18391951) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Scalp hair shape ( 26926045) Tuberculosis ( 20694014)
Interacting Genes		3 interacting genes: BLM RBBP8 TRAF6	37 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 EEF1A1 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PCNA PIN1 PRKDC PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 USP4
Entrez ID		1763	5932
HPRD ID		19123	04990
Ensembl ID		ENSG00000138346	ENSG00000101773
Uniprot IDs		P51530	A0A024RC34 Q99708
PDB IDs		5EAY	2L4Z 4D2H
Enriched GO Terms of Interacting Partners?
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