ACAN and LUM

Data Source:
HPRD (in vitro)

		ACAN	LUM
Description		aggrecan	lumican
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix	Extracellular Region Fibrillar Collagen Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance
	Biological Process	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Keratan Sulfate Catabolic Process	Visual Perception Response To Organic Cyclic Compound Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Transforming Growth Factor Beta1 Production Keratan Sulfate Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Response To Growth Factor
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Keratan sulfate biosynthesis Keratan sulfate degradation Integrin cell surface interactions ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs		Ilomastat	Copper
Diseases		Spondyloepiphyseal dysplasia, Kimberley type Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis
GWAS		Age-related hearing impairment ( 27764096) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Blood protein levels ( 30072576) Intraocular pressure ( 29617998) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure (alcohol consumption interaction) ( 24376456)
Interacting Genes		18 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF TNFAIP6 TNR	5 interacting genes: ACAN COL1A2 GNAQ MMP14 TRA2B
Entrez ID		176	4060
HPRD ID		01123	02793
Ensembl ID		ENSG00000157766	ENSG00000139329
Uniprot IDs		P16112	A0A384N669 P51884
PDB IDs		4MD4
Enriched GO Terms of Interacting Partners?
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