AGA and IGF2R

Data Source:
HPRD (in vitro)

		AGA	IGF2R
Description		aspartylglucosaminidase	insulin like growth factor 2 receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Endoplasmic Reticulum Azurophil Granule Lumen	Nuclear Envelope Lumen Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Endosome Membrane Membrane Clathrin Coat Transport Vesicle Endocytic Vesicle Trans-Golgi Network Transport Vesicle Clathrin-coated Vesicle Membrane Secretory Granule Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Protein Binding Peptidase Activity Protein Self-association	G-protein Alpha-subunit Binding Retinoic Acid Binding Insulin-like Growth Factor-activated Receptor Activity Protein Binding Insulin-like Growth Factor Binding Mannose Binding Enzyme Binding Insulin-like Growth Factor II Binding Signaling Receptor Activity Identical Protein Binding Phosphoprotein Binding Retromer Complex Binding
	Biological Process	Proteolysis Protein Deglycosylation Neutrophil Degranulation	Liver Development Receptor-mediated Endocytosis Lysosomal Transport Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Post-embryonic Development Animal Organ Regeneration Response To Retinoic Acid Positive Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation By Host Of Viral Process Insulin-like Growth Factor Receptor Signaling Pathway Membrane Organization Response To Tetrachloromethane
Pathways		Neutrophil degranulation	Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Mecasermin alpha-D-mannose 6-phosphate Cerliponase alfa Mecasermin rinfabate
Diseases		Aspartylglucosaminuria (AGU)	Hepatocellular carcinoma
GWAS		Chromosomal aberration frequency (chromatid type) ( 31586183) Colorectal cancer (calcium intake interaction) ( 25192705) Familial hepatitis B virus-related hepatocellular carcinoma ( 28662289) Metabolite levels ( 23823483) Motion sickness ( 25628336) Response to mTOR inhibitor (everolimus) ( 24009623) Serum selenium levels ( 23698163)	Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain lesion load ( 19010793) Coronary artery disease ( 29212778) LDL cholesterol levels ( 32203549) Lipoprotein (a) levels ( 26377243) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Periodontitis (CDC/AAP) ( 24024966) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		3 interacting genes: ALB IGF2R KRTAP1-3	14 interacting genes: AGA ATXN1 CREG1 CSNK2A1 CTSD GGA1 GGA2 GGA3 GZMB IGF2 PACS1 PLAU PLAUR PLIN3
Entrez ID		175	3482
HPRD ID		01949	00928
Ensembl ID		ENSG00000038002	ENSG00000197081
Uniprot IDs		P20933	P11717
PDB IDs		1APY 1APZ	1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y 6P8I 6V02 6Z30 6Z31 6Z32
Enriched GO Terms of Interacting Partners?
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