DLX3 and TDP2

Data Source:
BioGRID (two hybrid)

		DLX3	TDP2
Description		distal-less homeobox 3	tyrosyl-DNA phosphodiesterase 2
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GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity
	Biological Process	Blood Vessel Development Placenta Development Regulation Of Transcription By RNA Polymerase II Embryo Development Cell Differentiation Epithelial Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Transcription By RNA Polymerase II Odontoblast Differentiation	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Neuron Development Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways			Nonhomologous End-Joining (NHEJ)
Drugs
Diseases		Trichodentoosseous dysplasia Amelogenesis imperfecta hypoplastic-hypomaturation with taurodontism (AIHHT)
GWAS		Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)	Colorectal or endometrial cancer ( 26621817)
Interacting Genes		5 interacting genes: BANP POU4F2 PRKCA TBL1X TDP2	35 interacting genes: AKAP9 ATP5MC2 ATXN1 BLK BTBD2 C2orf88 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2
Entrez ID		1747	51567
HPRD ID		02752	05771
Ensembl ID		ENSG00000064195	ENSG00000111802
Uniprot IDs		O60479	A0A384MDM5 O95551
PDB IDs		4XRS	5INO 5J3P 5J3S 6Q00 6Q01
Enriched GO Terms of Interacting Partners?
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