AFP and PIDD1

Data Source:
BioGRID (two hybrid)

		AFP	PIDD1
Description		alpha fetoprotein	p53-induced death domain protein 1
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Fatty Acid Binding Protein Binding Zinc Ion Binding	Endopeptidase Activity Death Receptor Binding Protein Binding
	Biological Process	Transport Post-translational Protein Modification Cellular Protein Metabolic Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)	Breast cancer ( 29059683)
Interacting Genes		14 interacting genes: AP4S1 CASP3 CCR5 CREBBP EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 PTEN SGSM2 SIRT1 XIAP	15 interacting genes: AFP CASP2 CCDC85B CRADD EFEMP2 FADD HSD17B14 KHDC4 MADD MAFG MDFI MTNR1B POGZ SOX8 TEAD3
Entrez ID		174	55367
HPRD ID		00074	11284
Ensembl ID		ENSG00000081051	ENSG00000177595
Uniprot IDs		P02771	Q9HB75
PDB IDs		3MRK	2OF5
Enriched GO Terms of Interacting Partners?
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