CYB5R3 and RPS6KB1

Data Source:
BioGRID (biochemical)

		CYB5R3	RPS6KB1
Description		cytochrome b5 reductase 3	ribosomal protein S6 kinase B1
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cell Surface Neuron Projection Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding Nitrite Reductase (NO-forming) Activity NAD Binding FAD Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity PDZ Domain Binding Peptide Binding Identical Protein Binding Protein Phosphatase 2A Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Blood Circulation L-ascorbic Acid Metabolic Process Neutrophil Degranulation	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response Skeletal Muscle Contraction Apoptotic Process Signal Transduction Germ Cell Development Aging Response To Nutrient Long-term Memory Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Toxic Substance Response To Glucose Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-serine Phosphorylation Response To Nutrient Levels TOR Signaling Response To Lipopolysaccharide Cellular Response To Insulin Stimulus Response To Testosterone Response To Glucagon Response To Tumor Necrosis Factor Response To Drug Negative Regulation Of Apoptotic Process Response To Leucine Protein Kinase B Signaling Long-chain Fatty Acid Import Into Cell Response To Ethanol Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Interferon-gamma Cellular Response To Growth Factor Stimulus Cellular Response To Dexamethasone Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation	mTORC1-mediated signalling
Drugs		NADH Flavin adenine dinucleotide Copper
Diseases		Methemoglobinemia
GWAS		Initial pursuit acceleration ( 29064472)	C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Triglycerides ( 30275531)
Interacting Genes		61 interacting genes: ADAM33 AGTRAP AIG1 ALG8 AQP6 ASGR1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PNLIPRP1 REEP4 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 ZDHHC15	60 interacting genes: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DEPTOR DPPA4 EEF2K EIF3B EIF3F EIF4B EIF4EBP1 EP300 FBXO7 GDI2P1 GRIA1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 PIP4K2A POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RPS6 RPTOR SRC STK11 SYK TBK1 TERT TRAF4 URI1 USP11 XPO1
Entrez ID		1727	6198
HPRD ID		08942	10202
Ensembl ID		ENSG00000100243	ENSG00000108443
Uniprot IDs		P00387	P23443
PDB IDs		1M91 1UMK	3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK
Enriched GO Terms of Interacting Partners?
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