PPP1R18 and SPDL1

Data Source:
BioGRID (two hybrid)

		PPP1R18	SPDL1
Description		protein phosphatase 1 regulatory subunit 18	spindle apparatus coiled-coil protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Spindle Pole Condensed Chromosome Outer Kinetochore Nucleus Microtubule Organizing Center Cytosol
	Molecular Function	Actin Binding Protein Binding Phosphatase Binding	Protein Binding Enzyme Binding Kinetochore Binding
	Biological Process		Establishment Of Mitotic Spindle Orientation Mitotic Metaphase Plate Congression Mitotic Spindle Assembly Checkpoint Cell Migration Protein Localization To Kinetochore Cell Division
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Hemoglobin levels ( 32327693) Lung cancer ( 28604730)
Interacting Genes		80 interacting genes: ABRA ACTN3 BICD2 CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CCDC88B CDR2L CEP70 COG6 DES DZIP1 EIF3L FAM9B FHL5 FSD2 GCC1 GFAP GMCL1 GOLGA2 GOLGA6L9 GOPC GRIPAP1 GTPBP3 HAP1 HOMER3 HOOK2 HSF2BP IKZF3 KASH5 KCTD9 KRT13 KRT15 KRT16 KRT19 KRT27 KRT31 KRT33B KRT34 KRT36 KRT40 LDOC1 LZTS1 LZTS2 MAD1L1 MAPK1 MEOX2 MID2 MRPL38 MTUS2 NACA NEFL PDE4DIP PIBF1 PLEKHF2 PPP1CA PPP1CC PPP1R13B PRPH SORBS3 SPDL1 STX11 TCF4 TEX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TRIM62 TRIM69 TSC1 TSGA10 VIM VPS52 ZMYND12 ZRANB1	10 interacting genes: CA8 CEP126 DNAAF4 GPS2 ITSN1 PPP1R18 RTP5 TRAF4 USP15 USP45
Entrez ID		170954	54908
HPRD ID		11172	08623
Ensembl ID		ENSG00000146112	ENSG00000040275
Uniprot IDs		A0A024RCJ8 Q6NYC8	Q96EA4
PDB IDs
Enriched GO Terms of Interacting Partners?
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